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Stress induces neuronal death in the hippocampus of castrated rats
TLDR
Findings indicate that stress can contribute to neuronal degeneration associated with hypogonadal conditions such as aging. Expand
Trophic effect of erythropoietin and other hematopoietic factors on central cholinergic neurons in vitro and in vivo
TLDR
The results suggest that some of the hematopoietic factors act on cholinergic neurons as 'neurotrophic factors' to influence the differentiation, maintenance and regeneration of these neurons. Expand
Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor.
TLDR
This analysis showed that the beta APP is normally processed into a complex set of 8- to 12-kilodalton carboxyl-terminal derivatives, and the two largest derivatives in human brain have the entire beta AP at or near their amino terminus and are likely to be intermediates in the pathway leading to amyloid deposition. Expand
Alzheimer's disease amyloid beta-clipping enzyme (APP secretase): identification, purification, and characterization of the enzyme.
TLDR
Two synthetic substrates of APP secret enzyme are prepared, both of which contain the cleavage point and are much more sensitive than substrates previously available to identify APP secretase, and an intracellular proteinase is found that has APPsecretase activity. Expand
DM-20, a proteolipid apoprotein, is an encephalitogen of acute and relapsing autoimmune encephalomyelitis in mice.
TLDR
This DM-20-induced EAE in mice may provide a valuable model because it is similar to multiple sclerosis and because it can be induced in inbred mice in which immune mechanisms can be easily studied. Expand
No effect of anti-leprosy drugs in the prevention of Alzheimer’s disease and β-amyloid neurotoxicity
TLDR
The present study suggests that anti-leprosy treatments do not prevent the onset of AD and it is now important to examine the infection of Mycobacterium leprae in the central nervous system to clarify the reason for the low prevalence of senile dementia, and low frequency of Abeta deposition in leprosy patients. Expand
Chronic experimental allergic encephalomyelitis in guinea pigs induced by proteolipid protein
TLDR
It is suggested that PLP is encephalitogenic and produces demyelination in the central nervous system without contamination by MBP or GC in Hartley guinea pigs. Expand
Developmental and aging changes in the expression patterns of beta-amyloid in the brains of normal and down syndrome cases
TLDR
The results indicate that the A4 protein is a developmental protein, and its reappearance in Alzheimer and adult Down syndrome brains may be related to the regeneration process. Expand
Studies of experimental allergic encephalomyelitis by using encephalitogenic T cell lines and clones in euthymic and athymic mice.
TLDR
Results indicate that the entire clinical course of acute EAE can be elicited by a single population of MBP-reactive T cells in the absence of the thymus and other populations of primed or unprimed T cells. Expand
Thioredoxin from activated macrophages as a trophic factor for central cholinergic neurons in vitro.
TLDR
The conditioned medium from gamma-interferon-stimulated macrophages elevated the choline acetyltransferase activity in mouse septal neurons as well as in cholinergic hybrid cell lines SN6.10.2.2 in vitro and the neurotrophic activity of recombinant TRX was confirmed. Expand
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