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The Common Function of a Novel Subfamily of B-Box Zinc Finger Proteins with Reference to Circadian-Associated Events in Arabidopsis thaliana
TLDR
A small subfamily of double B-box zinc finger genes, encoding eight putative transcription factors, were characterized with reference to the circadian rhythm and the early photomorphogenic regulation of hypocotyl elongation in response to light signals, and it was found that the transcriptions of five DBB genes were under the control of circadian rhythm. Expand
A Sulforaphane Analogue That Potently Activates the Nrf2-dependent Detoxification Pathway*
TLDR
The observations that 7-MSHI was rapidly absorbed into the body and induced hepatic phase II detoxification enzymes more potently than sulforaphane, suggest that 6-HITC is a potential activator of the Nrf2/ARE-dependent detoxification pathway. Expand
Lipid Peroxidation-Dependent Cell Death Regulated by GPx4 and Ferroptosis.
TLDR
The results indicate that suppression of phospholipid peroxidation is essential for cell survival in normal tissues in mice and indicated the possibility that the mechanism of GPx4-depleted cell death might be different from that of ferroptosis induced by erastin and RSL3. Expand
15-Deoxy-Delta(12,14)-prostaglandin J(2): the endogenous electrophile that induces neuronal apoptosis.
TLDR
The 15d-PGJ(2) induced accumulation and phosphorylation of p53, which was accompanied by a preferential redistribution of the p53 protein in the nuclei of the cells and by a time-dependent increase in p53 DNA binding activity, suggesting that p53 accumulated in response to the treatment with 15d (PGJ) was functional. Expand
15-Deoxy-Δ12,14-prostaglandin J2: The endogenous electrophile that induces neuronal apoptosis
TLDR
The 15d-PGJ2-induced accumulation of p53 resulted in the activation of a death-inducing caspase cascade mediated by Fas and the Fas ligand and was accompanied by a preferential redistribution of the p53 protein in the nuclei of the cells and by a time-dependent increase in p53 DNA binding activity, suggesting that p53 accumulated in response to the treatment with15d- PGJ2 was functional. Expand
A Drosophila haemocyte-specific protein, hemolectin, similar to human von Willebrand factor.
TLDR
A novel Drosophila protein of approximately 400 kDa, hemolectin (d-Hml), secreted from haemocyte-derived Kc167 cells, which was detected in late embryos and larvae and induced by injury at any position on the body. Expand
Cyclopentenone Prostaglandins as Potential Inducers of Phase II Detoxification Enzymes
TLDR
A cell culture system that potently responds to phenolic antioxidants and found that antitumor prostaglandins (PGs) are potential inducers of GSTs, and suggests that 15-deoxy-Δ12,14-PGJ2 induces the expression of the ratGSTP1 gene through binding of proteins, including c-Jun, to a specific GPEI. Expand
Progression of alcoholic and non-alcoholic steatohepatitis: common metabolic aspects of innate immune system and oxidative stress.
TLDR
The important role of gut-derived bacterial toxins, the innate immune system, and oxidative stress in the common pathogenic mechanism in ALD and NASH progression is emphasized. Expand
Pivotal role of electrophilicity in glutathione S-transferase induction by tert-butylhydroquinone.
TLDR
It is concluded that an electrophilic quinone oxidation product that reacts with intracellular nucleophiles including protein thiol or GSH plays a major role in the GSTP1 gene expression. Expand
A Lipid Peroxidation-derived Inflammatory Mediator
TLDR
Findings suggest that HNE accumulated in macrophages/foam cells may represent an inflammatory mediator that plays a role in stimulation of the inflammatory response and contributes to the progression of atherogenesis. Expand
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