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Proposal of a computed tomography classification for hepatic alveolar echinococcosis.
The proposed CT-morphological classification (EMUC-CT) is intended to facilitate the recognition and interpretation of lesions in hepatic alveolar echinococcosis and shall assist in the context of scientific studies to improve the comparability of CT findings. Expand
First Demonstration of Leukemia Imaging with the Proliferation Marker 18F-Fluorodeoxythymidine
This pilot study indicated that PET using 18F-FLT is able to visualize extramedullary manifestation sites of AML and reflects disease activity. Expand
Radioimmunotherapy with Anti-CD66 Antibody: Improving the Biodistribution Using a Physiologically Based Pharmacokinetic Model
Simulations indicate that an improvement of radioimmunotherapy with anti-CD66 antibody is achievable by reducing the amount of administered antibody; for example, the residence time of the red marrow could be increased by a factor of 1.9 ± 0.3 using 0.27 mg of anti- CD66 antibody. Expand
Infiltration of inorganic compounds from the Glatt River, Switzerland, into a groundwater aquifer
The behavior of dissolved (<0.45 μm) inorganic compounds during infiltration of river water into the adjacent aquifer (unconsolidated glacio-fluvial sediments) was investigated at the Glatt River,Expand
Quantitative imaging of yttrium-86 PET with the ECAT EXACT HR+ in 2D mode.
Improved uniformity and quantitative accuracy in 86Y-PET measurements with the ECAT EXACT HR+. Expand
New molecular markers for prostate tumor imaging: a study on 2-methylene substituted fatty acids as new AMACR inhibitors.
The development of prostate carcinoma is associated with alterations in fatty acid metabolism. α-Methylacyl-CoA racemase (AMACR) is a peroxisomal and mitochondrial enzyme that catalysesExpand
Surgical treatment of melanoma in pregnancy: a practical guideline
It is crucial to clearly inform patients that – based on existing medical experience – pregnancy by itself is no reason to hold off on any type of necessary melanoma surgery, but various parameters such as preoperative imaging procedures, positioning on the operating table, monitoring, anesthesia, and perioperative medication require certain adjustments in order to comply with this special situation. Expand
Synthesis of BACE Inhibitor LY2886721. Part II. Isoxazolidines as Precursors to Chiral Aminothiazines, Selective Peptide Coupling, and a Controlled Reactive Crystallization
An efficient synthesis of LY2886721 (1) in five steps and 46% overall yield from the chiral nitrone cycloadduct 2 is presented. Minimizing formation of a des-fluoro impurity during hydrogenolysis toExpand
Synthesis of BACE Inhibitor LY2886721. Part I. An Asymmetric Nitrone Cycloaddition Strategy
A scalable, asymmetric synthesis of (3aS,6aS)-6a-(5-bromo-2-fluorophenyl)-1-((R)-1-phenylpropyl)tetrahydro-1H,3H-furo[3,4-c]isoxazole, a key intermediate in the synthesis of LY2886721, is reported.Expand