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Interleukin-17 promotes angiogenesis and tumor growth.
A novel role for IL-17 is revealed as a CD4 T-cell-derived mediator of angiogenesis that stimulates vascular endothelial cell migration and cord formation and regulates production of a variety of proangiogenic factors.
Establishment of a new extrahepatic bile duct carcinoma cell line, TFK-1.
TFK-1 is the third cell line established from extrahepatic bile duct carcinomas in the world literature, and should provide useful information on various aspects of this type of neoplasm.
Screening the p53 status of human cell lines using a yeast functional assay
The results strongly support the previous findings that p53 inactivation is one of the most frequent genetic events that occurs during carcinogenesis and immortalization.
Human CD4+ central and effector memory T cells produce IL-21: effect on cytokine-driven proliferation of CD4+ T cell subsets.
The functional analysis found that IL-21 significantly enhanced the cytokine-driven proliferation of CD4(+) helper T cells synergistically with IL-7 and IL-15 without T cell activation stimuli and may have a supportive role in the maintenance of CD 4(+) T cell subsets.
A novel adenovirus expressing human 4–1BB ligand enhances antitumor immunity
Significant tumor growth inhibition was observed in cholangiocarcinoma-grafted severe combined immunodeficient mice to which Ad4–1BBL and T-LAK cells were administered when tumor size exceeded 5 mm in diameter, providing strong evidence in support of the efficacy of adenovirally delivered 4–1 BBL for genetic immunotherapy of cancer.
A greatly simplified method of establishing B-lymphoblastoid cell lines.
Ten lymphoblastoid cell lines were established by Epstein-Barr virus-induced transformation directly from 0.04 to 0.15 ml of peripheral whole blood of one patient with xeroderma pigmentosum and four
Highly Effective Recombinant Format of a Humanized IgG-like Bispecific Antibody for Cancer Immunotherapy with Retargeting of Lymphocytes to Tumor Cells*
The results suggested that the intense antitumor activity of hEx3 is attributable to the multivalency and the presence of the fused human Fc, a hypothesis that was supported by the results of flow cytometry, PBMC proliferation assay, and protein kinase inhibition assay.