T. Kristian

Publications91
h-index37
Citations4,760
Highly Influential Citations122
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Calcium in ischemic cell death.
BACKGROUND This review article deals with the role of calcium in ischemic cell death. A calcium-related mechanism was proposed more than two decades ago to explain cell necrosis incurred in cardiac… Expand
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Acidosis-related damage.
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Differential Neuroprotection by Cyclosporin A and FK506 Following Ischemia Corresponds with Differing Abilities to Inhibit Calcineurin and the Mitochondrial Permeability Transition
Transient global or forebrain ischemia leads to severe brain damage following delayed neuronal cell death. We previously reported that cyclosporin A (CsA) provides near total suppression of brain… Expand
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Extracellular potassium in a neocortical core area after transient focal ischemia.
BACKGROUND AND PURPOSE Occlusion of the middle cerebral artery (MCAO) results in bioenergetic failure in the densely ischemic core areas. During reperfusion, transient recovery of the bioenergetic… Expand
  • 79
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Energy metabolism, ion homeostasis, and cell damage in the brain.
observed neither on metabolic deprivation nor on depolarization, but only after treatment with excitotoxins [7,9]. In related experiments (results not shown) using ‘T-m.r. to study flux through… Expand
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Metabolic stages, mitochondria and calcium in hypoxic/ischemic brain damage.
  • T. Kristian
  • Biology, Medicine
  • Cell calcium
  • 1 September 2004
Cerebral hypoxia/ischemia leads to mitochondrial dysfunction due to lack of oxygen leaving the glycolytic metabolism as a main pathway for ATP production. Inhibition of mitochondrial respiration thus… Expand
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Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model
BackgroundMitochondrial dysfunction is a hallmark of neurodegenerative diseases including Alzheimer’s disease (AD), with morphological and functional abnormalities limiting the electron transport… Expand
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Characteristics of the Calcium‐Triggered Mitochondrial Permeability Transition in Nonsynaptic Brain Mitochondria
Abstract: The objective of the present study was to assess the capacity of nonsynaptic brain mitochondria to accumulate Ca2+ when subjected to repeated Ca2+ loads, and to explore under what… Expand
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Calcium metabolism of focal and penumbral tissues in rats subjected to transient middle cerebral artery occlusion
Abstract The present experiments were undertaken to define changes in tissue calcium metabolism in focal and perifocal (“penumbral”) tissues following 2 h of transient middle cerebral artery… Expand
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Hyperoxic reperfusion after global cerebral ischemia promotes inflammation and long-term hippocampal neuronal death.
In this study we tested the hypothesis that long-term neuropathological outcome is worsened by hyperoxic compared to normoxic reperfusion in a rat global cerebral ischemia model. Adult male rats were… Expand
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