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Mechanical failure modes of chronically implanted planar silicon-based neural probes for laminar recording.
Several modes of mechanical failure of chronically implanted planar silicon electrodes are found that result in degradation and/or loss of recording, highlighting the importance of strains and material properties of various subcomponents within an electrode array. Expand
Glial responses to implanted electrodes in the brain
The role of glia as an effector of the performance and integration of devices implanted in the brain, and the implications of this for device development are discussed. Expand
Chronic tissue response to carboxymethyl cellulose based dissolvable insertion needle for ultra-small neural probes.
- T. Kozai, Zhannetta V. Gugel, +6 authors X. Cui
- Materials Science, Medicine
- 1 November 2014
A non-cytotoxic, carboxymethylcellulose (CMC) based dissolvable delivery vehicle (shuttle) to provide the mechanical support for insertion of ultra-small, ultra-compliant microfabricated neural probes shows great promise facilitating the implantation of nontraditional ultra- small, and ultra- Compliant probes. Expand
Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy.
The results suggest that the L1 surface treatment works in an acute setting by microglial mediated mechanisms. Expand
In vivo imaging of calcium and glutamate responses to intracortical microstimulation reveals distinct temporal responses of the neuropil and somatic compartments in layer II/III neurons.
Results demonstrate that increasing amplitude can increase the radius and intensity of neural recruitment, but it also alters the temporal response of some neurons, which suggests that increasing the amplitude of ICMS device stimulation may fundamentally alter the temporal neural response. Expand
Effects of caspase-1 knockout on chronic neural recording quality and longevity: insight into cellular and molecular mechanisms of the reactive tissue response.
Electrophysiology recording showed significantly improved single-unit recording performance of caspase-1 KO mice compared to wild type C57B6 (WT) mice over the course of up to 6 months for the majority of the depth, suggesting milder glia scarring in these mice. Expand
Photoelectric artefact from optogenetics and imaging on microelectrodes and bioelectronics: New Challenges and Opportunities.
This review covers four major topics: material dependent properties of the photoelectric effect (conductor, semiconductor, organic, photoelectric work function (band gap), strategies and limitations for avoiding/minimizing photoelectric effects, advantages of and applications for light-based bioelectronics (photo-bioelectronics), and opportunities for simultaneous applications with bioelectronic technologies. Expand
Melatonin improves quality and longevity of chronic neural recording.
Results demonstrate the potent effect of MT treatment in maintaining a high-quality electrode-tissue interface and suggest that MT promotes neuroprotection possibly through its anti-apoptotic, anti-inflammatory, and anti-oxidative properties. Expand
In vivo spatiotemporal dynamics of NG2 glia activity caused by neural electrode implantation.
Describing the early spatiotemporal dynamics of OPCs involved in the inflammatory response induced by microelectrode insertion may allow identification of alternative intervention targets for mitigating the formation of a glial scar and subsequent neurodegeneration that debilitates chronic neural interfaces. Expand
Optogenetic investigation of the variable neurovascular coupling along the interhemispheric circuits
- B. Iordanova, A. Vazquez, T. Kozai, M. Fukuda, Seong-Gi Kim
- Computer Science, Medicine
- Journal of cerebral blood flow and metabolism…
- 26 January 2018
The findings suggest that functional hyperemia requires signals originating from the cell body and the hemodynamic response variability appears to reflect the balance between the post-synaptic excitation and inhibition. Expand