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Adrenocortical zonation in humans under normal and pathological conditions.
- K. Nishimoto, K. Nakagawa, +10 authors K. Mukai
- Biology, Medicine
- The Journal of clinical endocrinology and…
Investigating the localization of CYP11B2 and -B1 in human adrenal specimens by using developed antibodies capable of distinguishing the two enzymes from each other revealed a variegated zonation with cell clusters constitutively expressing CYP 11B2, which may provide a pathological confirmatory diagnosis of adrenocortical adenomas. Expand
A Multi-Institutional Validation of the Prognostic Value of the Neutrophil-to-Lymphocyte Ratio for Upper Tract Urothelial Carcinoma Treated with Radical Nephroureterectomy
Elevated pre-NLR was significantly associated with worse pathological features such as tumor grade 3, advanced pT stage, positive LVI, and lymph node involvement in RNU specimens, and elevated pre- NLR was an independent risk factor of disease recurrence and cancer-specific mortality in UTUC patients treated with RNU. Expand
Activation of the aryl hydrocarbon receptor pathway enhances cancer cell invasion by upregulating the MMP expression and is associated with poor prognosis in upper urinary tract urothelial cancer.
It is suggested that AhR plays a role in the invasiveness of UC cells and can serve as a marker for the prognosis of upper urinary tract UC. Expand
Angiotensin II type 1 receptor antagonist as an angiogenic inhibitor in prostate cancer
This study investigated the effects of AT1R blockade using candesartan in prostate cancer (PCa) using a novel methodology and found it to have a protective effect against cancer. Expand
The predictive value of C-reactive protein for prognosis in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy: a multi-institutional study.
Serum CRP may become a possible biomarker in UTUC, suggesting that patients with an elevated pre-CRP level could be predicted to have subsequent disease recurrence and cancer-specific mortality, while postoperative normalisation of CRP level was an independent predictor for prognosis. Expand
Expression of TNF‐α and CD44 is implicated in poor prognosis, cancer cell invasion, metastasis and resistance to the sunitinib treatment in clear cell renal cell carcinomas
- S. Mikami, R. Mizuno, T. Kosaka, H. Saya, M. Oya, Y. Okada
- International journal of cancer
- 1 April 2015
The data show that TNF‐α plays an important role in progression of ccRCCs by inducing EMT and CD44 expression, and suggest that CD44 induced by T NF‐α may be involved in the resistance to the sunitinib treatment. Expand
Increased RANKL expression is related to tumour migration and metastasis of renal cell carcinomas
The data suggest that the RANKL–RANK–OPG system is involved not only in the bone metastasis of RCCs but also in metastasis to other organs through the stimulation of cancer cell migration. Expand
Axillary reverse mapping using a fluorescence imaging system in breast cancer
- M. Noguchi, M. Noguchi, Y. Nakano, Y. Ohno, T. Kosaka
- Journal of surgical oncology
- 1 March 2012
The axillary reverse mapping (ARM) procedure is based on the hypothesis that the lymphatic drainage from the upper arm is different from that of the breast. However, the oncologic safety of the… Expand
Recent advances in renal cell carcinoma from a pathological point of view
Therapies targeted at the vascular endothelial growth factor pathway have become the standard treatment of metastatic RCC, and pathologists should take overall view of these as integrated pathology. Expand
Metastatic Behavior of Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy: Association with Primary Tumor Location
This multi-institutional study provided a detailed picture of metastatic behavior after RNU, and primary tumor locations were associated with unique patterns of metastasis spread in UTUC patients. Expand