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Phosphorylation of farnesol by a cell-free system from Botryococcus braunii.
TLDR
In in vitro experiments with a 10,000 x g supernatant of cell homogenate, squalene was synthesized from farnesyl diphosphate in the presence of NADPH or NADH, but botryococcenes were not synthesized under the same conditions.
Geranylgeranyl diphosphate synthase catalyzing the single condensation between isopentenyl diphosphate and farnesyl diphosphate.
TLDR
Results indicate that geranylgeranylated proteins as well as cholesterol, ubiquinone, dolichol, and farnesylated proteins are synthesised through a single condensation between isopentenyl diphosphate andFarnesyl dphosphate, which is the common intermediate at the branch point for the synthesis of geranylgered proteins.
Transmissibility of mouse AApoAII amyloid fibrils: inactivation by physical and chemical methods
TLDR
A distinct correlation was obtained between the amounts of amyloid fibril fibrils and the transmissibility ofAmyloid Fibrils, thereby indicating the essential role of fibrill conformation for transmission of ameloidosis.
Transmission of amyloidosis in offspring of mice with AApoAII amyloidosis.
TLDR
Transmission of amyloid fibrils (AApoAII) may induce a conformational change in endogenous apolipoprotein A-II and accelerate amyloidal deposition in mouse senile amyloidsosis and provide important insight into the etiology and pathogenesis of ameloid diseases.
Purification of geranylgeranyl diphosphate synthase from bovine brain.
TLDR
Results indicate that GGPP, a lipid precursor for the biosynthesis of a majority of prenylated proteins, is synthesized from DMAPP and IPP by the action of FPP synthase catalyzing the reactions C5-->C15 followed by theaction of GGPP synthasing the reaction C15-->C20.
Biosynthesis of prenyl diphosphates by cell-free extracts from mammalian tissues.
TLDR
The results indicate that the rate of de novo synthesis of geranylgeranyl diphosphate from mevalonic acid is comparable to that of farnesyl diph phosphate.
Amyloidosis Modifier Genes in the Less Amyloidogenic A/J Mouse Strain
TLDR
Perlecan and group II secretory phospholipase A2, located on the significantly linked region of chromosome 4, were compared in this study for understanding the genetic mechanism of amyloidosis-related diseases and their prevention.
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