• Publications
  • Influence
Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis.
Sesamol seems to be an almost equally potent chemopreventive agent in the promotion stage of cancer development employing the in vitro Epstein-Barr virus early antigen activation assay induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA).
Antiproliferative sesquiterpene lactones from the roots of Inula helenium.
The MeOH extract of the roots of Inula helenium showed a high inhibitory activity for cell growth against MK-1, HeLa and B16F10 cell lines. Significant activity was found in the hexane-soluble
Chemoprevention of DMBA-induced UV-B promoted, NOR-1-induced TPA promoted skin carcinogenesis, and DEN-induced phenobarbital promoted liver tumors in mice by extract of beetroot.
Findings suggest that beetroot, which is a regularly consumed natural product colorant is an effective cancer chemopreventive agent in mice, and warrants more attention for possible human applications in the control of malignancy.
Studies on inhibitors of skin tumor promotion, IX. Neolignans from Magnolia officinalis.
Three neolignans isolated from the bark of Magnolia officinalis as inhibitors of Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) might be valuable antitumor promoters.
Antitumor agents, 154. Cytotoxic and antimitotic flavonols from Polanisia dodecandra.
Compound 1 appears to be the first example of a flavonol to exhibit potent inhibition of tubulin polymerization and, therefore, warrants further investigation as an antimitotic agent.
Anti-AIDS agents, 21. Triterpenoid saponins as anti-HIV principles from fruits of Gleditsia japonica and Gymnocladus chinensis, and a structure-activity correlation.
Evaluation of the anti-HIV activities of the prosapogenins of 1 and2 suggested that the unusual monoterpenyl moieties in 1 and 2 are essential for their anti-hIV activity.
Anti-tumor-promoting activity of lignans from the aerial part of Saussurea medusa.
ARC-G exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse pulmonary tumors induced by 4-nitroquinoline-N-oxide as an initiator and glycerol as a promoter.
Studies on inhibitors of skin-tumor promotion. Inhibitory effects of triterpenes from Cochlospermum tinctorium on Epstein-Barr virus activation.
Arjunolic acid, an oleanene-type triterpene isolated from the rhizome of Cochlospermum tinctorium, its triacetate derivative, and their methyl esters were tested and their inhibitory effects on skin tumor promotors were found to be greater than those of previously studied natural products.
Antitumor agents, 82. Cytotoxic sapogenols from Aesculus hippocastanum.
Two cytotoxic sapogenols, the new hippocaesculin (1) and the known barringtogenol-C 21-angelate (2), were isolated from the acid hydrolysis product of a crude saponin fraction that was obtained from