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Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells.
During animal development, cells become progressively more restricted in the cell types to which they can give rise. In the central nervous system (CNS), for example, multipotential stem cells… Expand
Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line.
- T. Kondo, T. Setoguchi, T. Taga
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 20 January 2004
Both stem cells and cancer cells are thought to be capable of unlimited proliferation. Paradoxically, however, some cancers seem to contain stem-like cells (cancer stem cells). To help resolve this… Expand
The Id4 HLH protein and the timing of oligodendrocyte differentiation
An intracellular timer is thought to help control the timing of oligodendrocyte differentiation. We show here that the expression of the helix–loop–helix gene Id4 in oligodendrocyte precursor cells… Expand
Basic helix-loop-helix proteins and the timing of oligodendrocyte differentiation.
An intracellular timer in oligodendrocyte precursor cells is thought to help control the timing of their differentiation. We show here that the expression of the Hes5 and Mash1 genes, which encode… Expand
Essential roles of the Fas ligand in the development of hepatitis
The Fas ligand (FasL) is expressed in activated T cells and induces apoptosis in Fas-bearing cells. A cytotoxic T lymphocyte (CTL) clone specific for hepatitis B surface antigen (HBsAg) causes an… Expand
Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells.
We showed previously that purified rat oligodendrocyte precursor cells (OPCs) can be induced by extracellular signals to convert to multipotent neural stem-like cells (NSLCs), which can then generate… Expand
Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells
- C. Lyssiotis, J. Walker, C. Wu, T. Kondo, P. Schultz, X. Wu
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 18 September 2007
Recently, it was demonstrated that lineage-committed oligodendrocyte precursor cells (OPCs) can be converted to multipotent neural stem-like cells, capable of generating both neurons and glia after… Expand
Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver
Fas, a type I membrane protein that transduces an apoptotic signal, is expressed in lymphocytes as well as in various tissues such as the liver, lung and heart. The mouse lymphoproliferation (lpr)… Expand
PET imaging of brain tumor with [methyl-11C]choline.
- T. Hara, N. Kosaka, N. Shinoura, T. Kondo
- Chemistry, Medicine
- Journal of nuclear medicine : official…
- 1 June 1997
UNLABELLED This article describes a new method of [11C]choline synthesis for intravenous injection. We aimed at the utilization of this compound for brain tumor imaging with PET. METHODS After… Expand
A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo
- D. Hampton, R. A. Asher, T. Kondo, J. Steeves, M. Ramer, J. Fawcett
- Biology, Medicine
- The European journal of neuroscience
- 1 December 2007
Bone morphogenetic proteins (BMPs) and their endogenous inhibitors, including noggin, chordin and follistatin, have roles in pattern formation and fate specification of neuronal and glial cells… Expand