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Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells.
During animal development, cells become progressively more restricted in the cell types to which they can give rise. In the central nervous system (CNS), for example, multipotential stem cellsExpand
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Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line.
Both stem cells and cancer cells are thought to be capable of unlimited proliferation. Paradoxically, however, some cancers seem to contain stem-like cells (cancer stem cells). To help resolve thisExpand
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The Id4 HLH protein and the timing of oligodendrocyte differentiation
An intracellular timer is thought to help control the timing of oligodendrocyte differentiation. We show here that the expression of the helix–loop–helix gene Id4 in oligodendrocyte precursor cellsExpand
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Basic helix-loop-helix proteins and the timing of oligodendrocyte differentiation.
An intracellular timer in oligodendrocyte precursor cells is thought to help control the timing of their differentiation. We show here that the expression of the Hes5 and Mash1 genes, which encodeExpand
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Essential roles of the Fas ligand in the development of hepatitis
The Fas ligand (FasL) is expressed in activated T cells and induces apoptosis in Fas-bearing cells. A cytotoxic T lymphocyte (CTL) clone specific for hepatitis B surface antigen (HBsAg) causes anExpand
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Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells.
We showed previously that purified rat oligodendrocyte precursor cells (OPCs) can be induced by extracellular signals to convert to multipotent neural stem-like cells (NSLCs), which can then generateExpand
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Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells
Recently, it was demonstrated that lineage-committed oligodendrocyte precursor cells (OPCs) can be converted to multipotent neural stem-like cells, capable of generating both neurons and glia afterExpand
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Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver
Fas, a type I membrane protein that transduces an apoptotic signal, is expressed in lymphocytes as well as in various tissues such as the liver, lung and heart. The mouse lymphoproliferation (lpr)Expand
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PET imaging of brain tumor with [methyl-11C]choline.
UNLABELLED This article describes a new method of [11C]choline synthesis for intravenous injection. We aimed at the utilization of this compound for brain tumor imaging with PET. METHODS AfterExpand
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Sox11 prevents tumorigenesis of glioma-initiating cells by inducing neuronal differentiation.
Recent findings have shown that malignant tumors contain cancer-initiating cells (CIC), which self-renew and are tumorigenic. However, CICs have not been characterized properly due to lack ofExpand
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