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Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells.
TLDR
It is shown here that certain extracellular signals can induce oligodendrocyte precursor cells to revert to multipotential neural stem cells, which can self-renew and give rise to neurons and astrocytes, as well as to oligodends, which have greater developmental potential than previously thought.
Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line.
TLDR
It is demonstrated that in the absence of serum the combination of basic fibroblast growth factor and platelet-derived growth factor maintains SP cells in the C6 glioma cell line, and proposed that many cancer cell lines contain a minor subpopulation of stem cells that is enriched in an SP, can be maintained indefinitely in culture, and is crucial for their malignancy.
A regenerative approach to the treatment of multiple sclerosis
TLDR
Pharmacological studies indicate that benztropine functions by a mechanism that involves direct antagonism of M1 and/or M3 muscarinic receptors, which should facilitate the development of effective new therapies for the treatment of multiple sclerosis that complement established immunosuppressive approaches.
The Id4 HLH protein and the timing of oligodendrocyte differentiation
TLDR
It is shown that the expression of the helix–loop–helix gene Id4 in oligodendrocyte precursor cells decreases in vivo and in vitro with a time course expected if Id4 is part of the intracellular timer.
Essential roles of the Fas ligand in the development of hepatitis
TLDR
Results suggest that FasL has an essential role in the development of hepatitis and administration of the soluble form of Fas into HBsAg transgenic mice prevented the CTL-induced liver disease.
Basic helix-loop-helix proteins and the timing of oligodendrocyte differentiation.
TLDR
It is shown that enforced expression of Hes5 in purified precursor cells strong inhibits the normal increase in the thyroid hormone receptor protein TR(&bgr;)1, which is thought to be part of the timing mechanism; it also strongly inhibits the differentiation induced by either mitogen withdrawal or thyroid hormone treatment.
Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells
TLDR
A series of experiments demonstrates that global histone acetylation, induced by HDAC inhibition, can partially reverse the lineage restriction of OPCs, thereby inducing developmental plasticity.
Chromatin remodeling and histone modification in the conversion of oligodendrocyte precursors to neural stem cells.
TLDR
This work shows that purified rat oligodendrocyte precursor cells can be induced by extracellular signals to convert to multipotent neural stem-like cells (NSLCs), which can then generate both neurons and glial cells, and suggests that the conversion depends on progressive chromatin remodeling.
Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver
TLDR
The Fas system seems to play a role in the apoptotic process to maintain homeostasis of the liver as well as the peripheral lymphoid organs.
SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity
TLDR
Observations indicate that SOX2 has a role in maintenance of stemness and tumorigenicity of human lung adenocarcinoma CSCs/CICs and is a potential target for treatment.
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