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Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency.
TLDR
It is suggested that GH plays an essential role in the metabolic and redox regulation in the liver and the abnormal lipid profile concomitant with a marked reduction in oxidative stress.
Perilipin Overexpression in White Adipose Tissue Induces a Brown Fat-Like Phenotype
TLDR
These findings demonstrate that overexpression of PeriA in white adipocytes reduces lipid droplet size by decreasing FSP27 expression and thereby inducing a brown adipose tissue-like phenotype, and suggest that modulation of lipid droplets proteins inwhite adipocytes is a potential therapeutic strategy for the treatment of obesity and its related disorders.
A Comparison of the Effects of the GLP-1 Analogue Liraglutide and Insulin Glargine on Endothelial Function and Metabolic Parameters: A Randomized, Controlled Trial Sapporo Athero-Incretin Study 2
TLDR
Regardless of glycemic improvement, early liraglutide therapy did not affect endothelial function but may provide favorable effects on beta-cell function and cardioprotection in type 2 diabetics without advanced atherosclerosis.
Teichoic Acid Polymers Affect Expression and Localization of dl-Endopeptidase LytE Required for Lateral Cell Wall Hydrolysis in Bacillus subtilis
TLDR
It is demonstrated that teichoic acid polymers affect the expression and localization of a peptidoglycan hydrolase LytE required for lateral cell wall elongation, and bacteria drastically change their cell wall content to adapt to their environment.
The phenotype of infiltrating macrophages influences arteriosclerotic plaque vulnerability in the carotid artery.
p38 MAPK is a major regulator of MafA protein stability under oxidative stress.
TLDR
It is demonstrated that MafA protein stability in MIN6 cells and isolated mouse islets is regulated by both p38 MAPK and glycogen synthase kinase 3, and the p38MAPK pathway may represent a common mechanism for regulating MAFA levels under oxidative stress and basal and stimulatory glucose concentrations.
Involvement of pRB-related p107 Protein in the Inhibition of S Phase Progression in Response to Genotoxic Stress*
TLDR
The results indicate that p107 participates in an inhibition of cell cycle progression in response to DNA damage in S phase cells, and the exposure of cells to the DNA-damaging agent, cisplatin, provokes S phase arrest.
The Novel Mechanisms Concerning the Inhibitions of Palmitate-Induced Proinflammatory Factor Releases and Endogenous Cellular Stress with Astaxanthin on MIN6 β-Cells
TLDR
Astaxanthin diminishes the palmitate-stimulated increase in MCP-1 secretion via the downregulation of JNK pathways in MIN6 cells, and affects VEGF120 secretion through PI3K/Akt pathways.
Collective Inhibition of pRB Family Proteins by Phosphorylation in Cells with p16INK4a Loss or Cyclin E Overexpression*
TLDR
It is suggested that dysregulation of the pRB kinase provokes an aberrant cell cycle in a broader range of cell types than those induced by genetic inactivation of theRB gene.
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