• Publications
  • Influence
Expression of the O9 polysaccharide of Escherichia coli: sequencing of the E. coli O9 rfb gene cluster, characterization of mannosyl transferases, and evidence for an ATP-binding cassette transport
Analysis of the predicted amino acid sequence of the ORF261 and ORF431 proteins indicated that they function as components of an ATP-binding cassette transport system, and a possible correlation between the mechanism of polymerization and mode of membrane translocation of the products is discussed. Expand
Astrocyte elevated gene‐1 (AEG‐1) is induced by lipopolysaccharide as toll‐like receptor 4 (TLR4) ligand and regulates TLR4 signalling
Astrocyte elevated gene‐1 was suggested to be a L PS‐responsive gene and involved in LPS‐induced inflammatory response and the prevention of AEG‐1 expression inhibited LPS •induced tumour necrosis factor‐α and prostaglandin E2 production. Expand
Sendai Virus C Protein Plays a Role in Restricting PKR Activation by Limiting the Generation of Intracellular Double-Stranded RNA
It was found that the intracellular protein synthesis rate was maintained even after wild-type (wt) SeV infection, but markedly suppressed following C-knockout SeV infections, indicating the requirement of C protein for maintaining protein synthesis after infection. Expand
The STAT2 Activation Process Is a Crucial Target of Sendai Virus C Protein for the Blockade of Alpha Interferon Signaling
The C protein appears to participate in the inhibitory process for STAT2 activation through the STAT1 interaction, suggesting that theSTAT2 activation process is a crucial target for the blockade of IFN-α signaling. Expand
C and V proteins of Sendai virus target signaling pathways leading to IRF-3 activation for the negative regulation of interferon-beta production.
The results suggest that C, Y1, Y2, and V block signaling pathways leading to IRF-3 activation to downregulate IFN-beta production, which is essential for downregulation of interferon (IFN)-beta production. Expand
Paramyxovirus Accessory Proteins as Interferon Antagonists
A new role of the Paramyxovirus accessory proteins has been uncovered. The P gene of the subfamily Paramyxovirinae encodes accessory proteins including the V and/or C protein by means ofExpand
Knockout of the Sendai virus C gene eliminates the viral ability to prevent the interferon-alpha/beta-mediated responses.
Findings reveal crucial roles of the SeV C proteins in blocking IFN-alpha-mediated responses and the subsequent establishment of an anti-viral state. Expand
In vivo induction of apoptosis by influenza virus.
Results suggest that the influenza virus induces apoptosis in vivo, and Nick end-labelling of DNA in situ confirmed that such apoptotic cells had fragmented DNA. Expand
Paramyxovirus strategies for evading the interferon response
Two genera, the Respirovirus (Sendai virus (SeV) and human parainfluenza virus (hPIV3) and the Rubulavirus (simian virus (SV) 5, SV41, mumps virus and hPIV2), of the three in the subfamilyExpand
Sendai virus C protein physically associates with Stat1
The P/C gene of the Sendai virus encodes C protein, which plays a crucial role in counteracting the antiviral effect of interferon (IFN), and its underlying molecular mechanism remains to be defined. Expand