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The loss of circadian PAR bZip transcription factors results in epilepsy.
DBP (albumin D-site-binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor) are the three members of the PAR bZip (proline and acidic amino acid-rich basic leucine… Expand
Increase of extracellular dopamine in primate prefrontal cortex during a working memory task.
Increase of extracellular dopamine in primate prefrontal cortex during a working memory task. J. Neurophysiol. 78: 2795-2798, 1997. The dopamine innervation of the prefrontal cortex is involved… Expand
State-dependent activity of neurons in the perifornical hypothalamic area during sleep and waking
Neurons containing orexins are located in the perifornical hypothalamic area and are considered to have a role in sleep-wake regulation. To examine how this area is involved in the regulation of… Expand
CSF histamine contents in narcolepsy, idiopathic hypersomnia and obstructive sleep apnea syndrome.
STUDY OBJECTIVE To (1) replicate our prior result of low cerebrospinal fluid (CSF) histamine levels in human narcolepsy in a different sample population and to (2) evaluate if histamine contents are… Expand
Enhancement of acetylcholine release during paradoxical sleep in the dorsal tegmental field of the cat brain stem
Acetylcholine (ACh) in the brain stem has been implicated in the generation of paradoxical sleep (PS). In order to clarify the relationship between local ACh release in the dorsal tegmental field… Expand
Behavioral response and transmitter release during atonia elicited by medial medullary stimulation.
- Y. Lai, T. Kodama, E. Schenkel, J. Siegel
- Chemistry, Medicine
- Journal of neurophysiology
- 1 October 2010
Activation of the medial medulla is responsible for rapid eye movement (REM) sleep atonia and cataplexy. Dysfunction can cause REM sleep behavior disorder and other motor pathologies. Here we report… Expand
CSF histamine levels in rats reflect the central histamine neurotransmission
Reduced cerebrospinal fluid (CSF) histamine levels were found in human hypersomnia. To evaluate the functional significance of changes in CSF histamine levels, we measured the levels in rats across… Expand
Transcriptional regulation of the hypocretin/orexin gene by NR6A1.
- Susumu Tanaka, T. Kodama, +6 authors E. Mignot
- Biology, Medicine
- Biochemical and biophysical research…
- 10 December 2010
The hypocretin (also known as orexin) neuropeptide system coordinates the regulation of various physiological processes. A reduction in Nr6a1 expression was observed in hypocretin neuron-ablated… Expand
Chronic restraint stress triggers dopaminergic and noradrenergic neurodegeneration: Possible role of chronic stress in the onset of Parkinson’s disease
Parkinson's disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and, to a lesser extent, in the… Expand
Oral Administration of Methylphenidate (Ritalin) Affects Dopamine Release Differentially Between the Prefrontal Cortex and Striatum: A Microdialysis Study in the Monkey
- T. Kodama, T. Kojima, Y. Honda, T. Hosokawa, K. Tsutsui, Masataka Watanabe
- Psychology, Medicine
- The Journal of Neuroscience
- 1 March 2017
Methylphenidate (MPH; trade name Ritalin) is a widely used drug for the treatment of attention deficit hyperactivity disorder (ADHD) and is often used as a cognitive enhancer. Because MPH increases… Expand