T. Kocher

Publications216
h-index71
Citations24,196
Highly Influential Citations1,507
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Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers.
TLDR
The polymerase chain reaction is used to amplify homologous segments of mtDNA from more than 100 animal species, including mammals, birds, amphibians, fishes, and some invertebrates, and the unexpectedly wide taxonomic utility of these primers offers opportunities for phylogenetic and population research.
Evolution of the cytochrome b gene of mammals.
TLDR
Comparisons of these cytochrome b sequences support current structure-function models for this membrane-spanning protein, which suggests that the outer surface which includes the Qo redox center is more constrained than the remainder of the molecule, namely, the transmembrane segments and the surface that protrudes into the mitochondrial matrix.
Adaptive evolution and explosive speciation: the cichlid fish model
  • T. Kocher
  • Biology
    Nature Reviews Genetics
  • 1 April 2004
The cost of DNA sequencing continues to fall, which makes it feasible to develop genomic resources for new model species that are well suited for studying questions in evolutionary biology. The…
Monophyletic origin of Lake Victoria cichlid fishes suggested by mitochondrial DNA sequences
TLDR
This work sequenced up to 803 base pairs of mitochondrial DNA from 14 representative Victorian species and 23 additional African species to study the 'flock' of cichlid fishes in Lake Victoria.
Structure and evolution of teleost mitochondrial control regions
TLDR
The mitochondrial control region from 23 species representing six families of teleost fish is amplified and sequenced, suggesting that particular care should be taken to identify the most appropriate segment for studies of intraspecific variation.
Evolution of the cytochromeb gene of mammals
TLDR
Comparisons of these cytochromeb sequences support current structure-function models for this membrane-spanning protein, including that part of the outer surface which includes the Qo redox center is more constrained than the remainder of the molecule, namely, the transmembrane segments and the surface that protrudes into the mitochondrial matrix.
Evolution of NADH dehydrogenase subunit 2 in east African cichlid fish.
TLDR
Phylogenetic analysis of the sequences shows that the mtDNA variation in Lake Malawi cichlids is nested monophyletically within the range of variation shown by Tanganyikan cichLids, and Divergences among tribes are consistent with an intralacustrine radiation within the past 10 million years.
Patterns of nucleotide composition at fourfold degenerate sites of animal mitochondrial genomes
TLDR
Three statistics (%GC, GC-skew, and AT-s Skew) can be used to describe the overall patterns of nucleotide composition in DNA sequences, which reflect the substitution process in mitochondrial genomes.
Mitochondrial DNA sequences in single hairs from a southern African population.
TLDR
Evidence of geographic structuring of the mitochondrial diversity in Africa, together with knowledge of the rate of accumulation of base changes in human mtDNA, implies that the average rate at which female lineages have moved their home bases during hunter-gatherer times could be as low as 13 meters per year.
The genomic substrate for adaptive radiation in African cichlid fish
TLDR
It is concluded that a number of molecular mechanisms shaped East African cichlid genomes, and that amassing of standing variation during periods of relaxed purifying selection may have been important in facilitating subsequent evolutionary diversification.
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