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Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction.
Bone remodeling is performed by osteoclasts and osteoblasts at the bone surface. Inside of bone is a network of numerous osteocytes, whose specific function has remained an enigma. Here we describe aExpand
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Participation of Xanthine-Xanthine Oxidase System and Neutrophils in Development of Acute Gastric Mucosal Lesions in Rats with a Single Treatment of Compound 48/80, a Mast Cell Degranulator
The participation of xanthine-xanthine oxidaseand neutrophils in the development of acute gastricmucosal lesions was examined in rats injected once withcompound 48/80, a mast cell degranulator.Expand
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Selective peroxisome proliferator‐activated receptor‐&agr; modulator K‐877 regulates the expression of ATP‐binding cassette transporter A1 in pancreatic beta cells
Abstract ATP‐binding cassette transporter A1 (ABCA1) protein is a pivotal regulator of cholesterol and phospholipid efflux from cells to high‐density lipoprotein (HDL) particles. Pancreatic ABCA1Expand
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Superoxide Production at Phagosomal Cup/Phagosome through βI Protein Kinase C during FcγR-Mediated Phagocytosis in Microglia1
Protein kinase C (PKC) plays a prominent role in immune signaling. To elucidate the signal transduction in a respiratory burst and isoform-specific function of PKC during FcγR-mediated phagocytosis,Expand
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Relationship Between Changes of Active Oxygen Metabolism and Blood Flow and Formation, Progression, and Recovery of Lesions in Gastric Mucosa of Rats with a Single Treatment of Compound 48/80, a Mast
The relationship between the changes of activeoxygen metabolism and blood flow and the formation,progression, and recovery of lesions was examined in thegastric mucosa of rats treated once withExpand
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Combination treatment of hydrogen peroxide and X-rays induces apoptosis in human prostate cancer PC-3 cells.
PURPOSE To study the effect of hydrogen peroxide (H(2)O(2)) on radiation-induced apoptosis in human prostate cancer PC-3 cells. METHODS AND MATERIALS At 4h before the irradiation, PC-3 cells wereExpand
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Transdermal administration of lactoferrin with sophorolipid.
Lactoferrin (Lf), a multifunctional glycoprotein, is known to activate dermal fibroblasts. Enhancing percutaneous absorption without decreasing the activity of Lf is critical in making the dermalExpand
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Urinary γ-glutamyltransferase (GGT) as a potential marker of bone resorption
Abstract We recently identified γ-glutamyltransferase (GGT) as a novel bone-resorbing factor. The present study was undertaken to determine whether GGT is a marker of bone resorption in two geneticExpand
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Although aspirin therapy or high-dose γ-globulin therapy may be effective in the acute stage of Kawasaki disease, there was a 12.8% incidence of coronary lesions in nationwide survey. We treated 269Expand
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Effect of protein malnutrition on the skin epidermis of hairless mice.
The purpose of this study was to evaluate the effect of protein malnutrition on the skin epidermis of mice. A low protein diet induced thinning of the skin epidermis, a decrease of cell proliferativeExpand
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