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Vaccination of recurrent glioma patients with tumour lysate-pulsed dendritic cells elicits immune responses: results of a clinical phase I/II trial
In this Phase I/II trial, the patient's peripheral blood dendritic cells were pulsed with an autologous tumour lysate of the glioma. Seven patients with glioblastoma and three patients withExpand
Molecular cloning of a mouse G-protein-activated K+ channel (mGIRK1) and distinct distributions of three GIRK (GIRK1, 2 and 3) mRNAs in mouse brain.
We cloned the mouse brain G-protein-activated K+ channel 1 (mGIRK1) cDNA and determined the complete nucleotide and amino acid sequences of the coding region. In in situ hybridization using specificExpand
Effects of σ ligands on the nociceptin/orphanin FQ receptor co‐expressed with the G‐protein‐activated K+ channel in Xenopus oocytes
Taking advantage of the functional coupling of the nociceptin/orphanin FQ receptor with the G‐protein‐activated inwardly rectifying K+ (GIRK) channel, we investigated the effects of various σ ligandsExpand
The Untranslated Region of μ-Opioid Receptor mRNA Contributes to Reduced Opioid Sensitivity in CXBK Mice
It is well known that there are individual differences in a sensitivity to analgesics. Several lines of evidence have suggested that the level of opioid-induced analgesia is dependent on the level ofExpand
Inhibition by various antipsychotic drugs of the G‐protein‐activated inwardly rectifying K+ (GIRK) channels expressed in Xenopus oocytes
To investigate the effects of various chemical classes of antipsychotic drugs: haloperidol, thioridazine, pimozide and clozapine, on the G‐protein‐activated inwardly rectifying K+ (GIRK) channels, weExpand
Comparison of the Three Mouse G‐Protein‐Activated K+ (GIRK) Channels and Functional Couplings of the Opioid Receptors with the GIRKI Channel a
The opioid, dopamine and serotonin receptors are crucial molecules in drug addictions. Previous studies of signal transduction pathways from these receptors have shown that their activation altersExpand
Effects of sigma ligands on the cloned μ‐, δ‐ and k‐opioid receptors co‐expressed with G‐protein‐activated K+ (GIRK) channel in Xenopus oocytes
1 Taking advantage of the functional coupling of the opioid receptors with the G‐protein‐activated K+ (GIRK) channel, we investigated the effects of sigma (σ) ligands of various structural andExpand
Functional couplings of the delta- and the kappa-opioid receptors with the G-protein-activated K+ channel.
The delta- and the kappa-opioid receptors were individually co-expressed with the G-protein-activated K+ (GIRK1) channel in Xenopus oocytes. Stimulation of these opioid receptors with selectiveExpand
Unique behavioural phenotypes of recombinant-inbred CXBK mice: partial deficiency of sensitivity to mu- and kappa-agonists.
Recombinant-inbred CXBK mice have been used for various studies as putative mu-opioid-receptor deficient mice. However, CXBK mice have never been compared with gene-targeting mice lacking theExpand
Effects of clozapine on the delta- and kappa-opioid receptors and the G-protein-activated K+ (GIRK) channel expressed in Xenopus oocytes.
1. To investigate the effects of clozapine, an atypical antipsychotic, on the cloned mu-, delta- and kappa-opioid receptors and G-protein-activated inwardly rectifying K+ (GIRK) channel, we performedExpand