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Functional coupling of the nociceptin/orphanin FQ receptor with the G-protein-activated K+ (GIRK) channel.
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Molecular cloning of a mouse G-protein-activated K+ channel (mGIRK1) and distinct distributions of three GIRK (GIRK1, 2 and 3) mRNAs in mouse brain.
TLDR
The cloned mouse brain G-protein-activated K+ channel 1 (mGIRK1) cDNA was cloned and the complete nucleotide and amino acid sequences of the coding region were determined, suggesting that mGirK channels may be essential in most brain regions in a signal transduction mediated by various G- protein-coupled receptors.
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Atypical amyotrophic lateral sclerosis with dementia mimicking frontal Pick's disease: a report of an autopsy case with a clinical course of 15 years
TLDR
This case was atypical ALS with dementia of long disease duration and the possibility that motor neuron disease-inclusion dementia with a long clinical course may develop into ALS in the final stage of the illness is noted.
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Deprenyl and pergolide rescue spinal motor neurons from axotomy-induced neuronal death in the neonatal rat.
TLDR
Co-administration of deprenyl and pergolide is more effective than either agent alone but not significant, which is consistent with the idea that deprenYL and perGolide are survival factors for developing spinal motor neurons.
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Neuroprotective effect of basic fibroblast growth factor on wobbler mouse motor neuron disease.
TLDR
It is reported that basic fibroblast growth factor delays progression of motor neuron disease (MND) in the wobbler mouse and provides a rationale that bFGF may have therapeutic potential in peripheral motor neuropathy or MND.
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Comparison of the Three Mouse G‐Protein‐Activated K+ (GIRK) Channels and Functional Couplings of the Opioid Receptors with the GIRKI Channel a
TLDR
The G-protein-activated K+ channel (GIRK channel), a member of a family of inward-rectifier K+ channels, is considered to play an important role in signal transduction from the opioid, dopamine and serotonin receptors.
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Inhibition by various antipsychotic drugs of the G‐protein‐activated inwardly rectifying K+ (GIRK) channels expressed in Xenopus oocytes
TLDR
The results suggest that inhibition of both types of GIRK channels by these drugs underlies some of the side effects, in particular seizures and sinus tachycardia, observed in clinical practice.
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The Untranslated Region of μ-Opioid Receptor mRNA Contributes to Reduced Opioid Sensitivity in CXBK Mice
TLDR
The present findings suggest that opioid sensitivity may vary, depending on differentμ-OR levels attributable to divergent UTR of μ-OR mRNA, based on individual differences in a sensitivity to analgesics.
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Effects of sigma ligands on the cloned μ‐, δ‐ and k‐opioid receptors co‐expressed with G‐protein‐activated K+ (GIRK) channel in Xenopus oocytes
TLDR
It is concluded that various σ ligands directly interact with the cloned μ‐, δ‐ and k‐opioid receptors in Xenopus oocytes, and the results suggest that the effects of the �o ligands may be partly mediated by the opioid receptors.
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Basic fibroblast growth factor and platelet-derived growth factor prevent the death of spinal motor neurons after sciatic nerve transection in the neonatal rats.
TLDR
It is reported that systemically administered basic fibroblast growth factor and platelet-derived growth factor prevented spinal motor neuron death in neonatal rats following sciatic nerve resection, indicating that basic Fibroblast Growth Factor and Platelet derived growth factor play a role for motor neuron survival in vivo.
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