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An Essential Role of Mast Cells in the Development of Airway Hyperresponsiveness in a Murine Asthma Model
Immunization of BALB/c mice with alum-adsorbed OVA, followed by three bronchoprovocations with aerosolized OVA, resulted in the development of airway hyperresponsiveness (AHR) and allergicExpand
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Disposition of idebenone (CV-2619), a new cerebral metabolism improving agent, in rats and dogs.
After oral administration of 14C-labeled idebenone (14C-CV-2619) to rats, the plasma 14C level reached a plateau at 15 min, which persisted till 8 h and then decreased with a half-life of 4.5 h. InExpand
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Arginine enhances induction of T helper 1 and T helper 2 cytokine synthesis by Peyer's patch alpha beta T cells and antigen-specific mucosal immune response.
The effects of arginine on cell proliferation and subsequent T helper (Th) 1 and Th 2 cytokine synthesis by murine Peyer's patch (PP) Th cells in vitro and the influence of arginine on the inductionExpand
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Structural features of an anti-diabetic polysaccharide (TAP) from Tremella aurantia.
The structure of an anti-diabetic polysaccharide (TAP) obtained from the fruiting bodies of Tremella aurantia was investigated by methylation analysis, Smith degradation, partial acid hydrolysis,Expand
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Mutagenic nitrated benzo[a]pyrene derivatives in the reaction product of benzo[a]pyrene in NO2-air in the presence of O3 or under photoirradiation.
In order to clarify the contribution of nitrated products to the direct-mutagenic activity of products of the reactions of benzo[a]pyrene in NO2-air under various conditions, heterogeneous reactionsExpand
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Production of antibody to aprotinin and location of this compound in bovine tissue.
Antibody to aprotinin was easily produced in rabbits by injecting an emulsion of Trasylol and adjuvant, and its specificity was confirmed by double diffusion, immunoelectrophoresis in gel, passiveExpand
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Metabolism of idebenone (CV-2619), a new cerebral metabolism improving agent: isolation and identification of metabolites in the rat and dog.
Metabolic studies of idebenone (CV-2619), a new cerebral metabolism improving agent, in the rat and dog by thin-layer chromatography, gas-liquid chromatography-mass spectrometry and fast atomExpand
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Pharmacokinetic analysis of pharmacological effects and drug disposition. II. Effects of salicylamide and afebrile rats.
The purpose of this investigation was to represent quantitatively the relationship between the time course of pharmacological effects and drug disposition data after oral administration ofExpand
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Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb2 in streptozotocin-diabetic rats.
The effect of ginsenoside-Rb2 purified from ginseng was examined in streptozotocin-induced diabetic rats. The rats of the ginsenoside-Rb2-treated group showed a significant decrease of blood glucoseExpand
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