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The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
- Pedro A. Pérez-Mancera, Alistair G. Rust, +33 authors D. Tuveson
- Biology, Medicine
- 29 April 2012
Pancreatic ductal adenocarcinoma (PDA) remains a lethal malignancy despite much progress concerning its molecular characterization. PDA tumours harbour four signature somatic mutations in addition to… Expand
ALCAM/CD166 is overexpressed in colorectal carcinoma and correlates with shortened patient survival
- W. Weichert, T. Knösel, J. Bellach, M. Dietel, G. Kristiansen
- Journal of Clinical Pathology
- 27 October 2004
Background: Activated leucocyte cell adhesion molecule (ALCAM) has been implicated in tumorigenesis and tumour progression of malignant melanoma and prostate cancer. Aims: To clarify the expression… Expand
Google Goes Cancer: Improving Outcome Prediction for Cancer Patients by Network-Based Ranking of Marker Genes
- C. Winter, G. Kristiansen, +18 authors R. Grützmann
- Computer Science, Biology
- PLoS Comput. Biol.
- 1 May 2012
Predicting the clinical outcome of cancer patients based on the expression of marker genes in their tumors has received increasing interest in the past decade. Accurate predictors of outcome and… Expand
Nuclear export is essential for the tumor‐promoting activity of survivin
- S. Knauer, O. Krämer, +13 authors R. Stauber
- Biology, Medicine
- FASEB journal : official publication of the…
- 1 January 2007
Survivin appears to function as an apoptosis inhibitor and a regulator of cell division during development and tumorigenesis. Here we report the molecular characterization of the nucleocytoplasmic… Expand
MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression.
BACKGROUND & AIMS There has not been a broad analysis of the combined effects of altered activities of microRNAs (miRNAs) in pancreatic ductal adenocarcinoma (PDAC) cells, and it is unclear how these… Expand
Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis.
The programmed cell death 4 gene (PDCD4), a newly identified transformation suppressor, was analysed in lung tumour cell lines and primary lung carcinomas. Reduced PDCD4 mRNA expression was observed… Expand
TLE1 is a robust diagnostic biomarker for synovial sarcomas and correlates with t(X;18): analysis of 319 cases.
INTRODUCTION Genomewide expression profiling has identified a number of genes expressed at higher levels in synovial sarcoma than in other sarcomas. Our objectives in this study were (1) to test… Expand
Incidence of chromosomal imbalances in advanced colorectal carcinomas and their metastases
Abstract. Comparative genomic hybridization (CGH) was used to screen 54 advanced colon carcinomas, i.e., 24 primary tumors and 30 metastases, for chromosomal alterations. Using a sensitive… Expand
Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) has potential tumour-suppressive activity in human lung cancer.
- Y. Chen, M. Pacyna-Gengelbach, +9 authors I. Petersen
- Medicine, Biology
- The Journal of pathology
- 1 March 2007
The expression of insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) is decreased in various tumours, but the role of IGFBP-rP1 in lung cancer is not yet clear. In this study,… Expand
Nuclear relocation of STAT6 reliably predicts NAB2–STAT6 fusion for the diagnosis of solitary fibrous tumour
- C. Koelsche, L. Schweizer, +15 authors G. Mechtersheimer
- Medicine, Biology
- 1 November 2014
Nuclear relocation of STAT6 has been shown in tumours with NAB2–STAT6 fusion, and has been proposed as an ancillary marker for the diagnosis of solitary fibrous tumours (SFTs). The aim of this study… Expand