T. Kivelä

Publications404
h-index57
Citations10,417
Highly Influential Citations315
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Very long-term prognosis of patients with malignant uveal melanoma.
TLDR
Investigating the very long-term prognosis of patients with uveal melanoma and the clinical characteristics influencing it found cumulative incidences provide a sound basis for patient counseling and design of trials.
Trilateral retinoblastoma: a meta-analysis of hereditary retinoblastoma associated with primary ectopic intracranial retinoblastoma.
  • T. Kivelä
  • Medicine
    Journal of clinical oncology : official journal…
  • 1 June 1999
TLDR
The family history, age at diagnosis, and laterality of retinoblastoma in children with TRb resembled that of ordinary hereditary retin Oblastoma, and screening by neuroimaging could improve the cure rate.
Mutations in CTC1, encoding the CTS telomere maintenance complex component 1, cause cerebroretinal microangiopathy with calcifications and cysts.
TLDR
Preliminary functional experiments did not show evidence of severely affected telomere integrity in the affected individuals, and determining the underlying pathomechanisms associated with deficient CTC1 function will require further studies.
The Merkel cell and associated neoplasms in the eyelids and periocular region.
TLDR
The diagnosis is based on the frequent presence of neurofilaments and paranuclear aggregates of intermediate filaments in addition to features typical of normal Merkel cells, and the tumor often mimics lymphoma or undifferentiated carcinoma and frequently invades lymphatic vessels.
The epidemiological challenge of the most frequent eye cancer: retinoblastoma, an issue of birth and death
  • T. Kivelä
  • Medicine
    British Journal of Ophthalmology
  • 24 August 2009
TLDR
Many papers on retinoblastoma open with a statement that it is the most common primary intraocular cancer in children and a rare disease, but this claim is substantiated and its consequences evaluated.
Population-based assessment of clinical characteristics predicting outcome of conjunctival melanoma in whites.
TLDR
The incidence of conjunctival melanoma in the white population of Finland increased analogous to cutaneous melanoma, and nonlimbal tumors recur more often and are associated with decreased survival, independent of their greater thickness.
Ophthalmologic findings in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutation: a new type of hereditary metabolic chorioretinopathy.
TLDR
The chorioretinopathy and abnormal ERG precede the development of myopia and posterior staphyloma, which, in turn, coincide with the loss of macular vision, and the authors postulate that the RPE or choriocapillaris is primarily affected.
Tumor doubling times in metastatic malignant melanoma of the uvea: tumor progression before and after treatment.
TLDR
Current chemoimmunotherapy regimens slow down the growth rate of metastases even if objective response is not obtained, and a rational follow-up interval to detect metastatic uveal melanoma would be 4 to 6 months.
Staging of ciliary body and choroidal melanomas based on anatomic extent.
TLDR
This evidence-based anatomic classification provides a basis for staging ciliary body and choroidal melanomas in the seventh edition of the Cancer Staging Manual of the American Joint Committee on Cancer.
The IC3D classification of the corneal dystrophies.
TLDR
A new classification system for corneal dystrophies is developed, integrating up-to-date information on phenotypic description, pathologic examination, and genetic analysis with new genetic, clinical, and pathologic information.
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