• Publications
  • Influence
Signaling through the JAK/STAT pathway, recent advances and future challenges.
Investigation into the mechanism of cytokine signaling led to the discovery of the JAK/STAT pathway. Following the binding of cytokines to their cognate receptor, signal transducers and activators ofExpand
  • 982
  • 46
Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney.
Understanding the origin of scar-producing myofibroblasts is vital in discerning the mechanisms by which fibrosis develops in response to inflammatory injury. Using a transgenic reporter mouse modelExpand
  • 632
  • 34
Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis.
Activation and accumulation of cardiac fibroblasts, which result in excessive extracellular matrix deposition and consequent mechanical stiffness, myocyte uncoupling, and ischemia, are keyExpand
  • 303
  • 24
Origin of myofibroblasts in the fibrotic liver in mice
Significance Liver resident activated hepatic stellate cells (aHSCs), and activated portal fibroblasts (aPFs) are the major source of the fibrous scar in the liver. aPFs have been implicated in liverExpand
  • 248
  • 19
Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice.
BACKGROUND & AIMS Interleukin (IL)-17 signaling has been implicated in lung and skin fibrosis. We examined the role of IL-17 signaling in the pathogenesis of liver fibrosis in mice. METHODS UsingExpand
  • 351
  • 18
Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
Myofibroblasts produce the fibrous scar in hepatic fibrosis. In the carbon tetrachloride (CCl4) model of liver fibrosis, quiescent hepatic stellate cells (HSC) are activated to become myofibroblasts.Expand
  • 469
  • 17
Mechanisms of Fibrogenesis
Fibrogenesis is a mechanism of wound healing and repair. However, prolonged injury causes deregulation of normal processes and results in extensive deposition of extracellular matrix (ECM) proteinsExpand
  • 345
  • 17
Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis
Liver fibrosis is caused by many chronic diseases. Liver injury results in activation of collagen‐producing cells and excessive deposition of extracellular matrix proteins. This process isExpand
  • 213
  • 17
New mitochondrial DNA synthesis enables NLRP3 inflammasome activation
Dysregulated NLRP3 inflammasome activity results in uncontrolled inflammation, which underlies many chronic diseases. Although mitochondrial damage is needed for the assembly and activation of theExpand
  • 172
  • 11
Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis.
BACKGROUND/AIMS Hepatic stellate cells (HSCs) play a key role in hepatic fibrogenesis. However, their origin is still unknown. We tested the hypothesis that bone marrow (BM) contributes to theExpand
  • 419
  • 8