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Anti-obesity and anti-diabetic activities of a new beta3 adrenergic receptor agonist, (S)-(Z)-[4-[[1-[2-[(2-hydroxy-3-phenoxypropyl)]amino]ethyl]-1-propenyl] phenoxy] acetic acid ethanedioic acid
The results indicated that SWR-0342SA is a selective beta3-AR agonist, and possesses potent anti-di diabetic activity, and that the anti-obesity activity is inferior to theAnti-diabetic activity. Expand
Structural analyses of a precursory substance of bitterness: new polyisoprenepolyols isolated from an edible mushroom (Hypsizigusmarmoreus) by fast atom bombardment mass spectrometry.
New polyisoprenepolyols (hypsiziprenol AA and BA) were isolated from an edible mushroom and were found to have antitumor activity on NCI-H292 and EL-4 cell lines. Expand
cAMP-independent chloride secretion activated by a vasoactive intestinal peptide in a monolayer culture of human bronchial epithelial cells.
It is suggested that Cl- secretion by VIP is not related to the raised intracellular cAMP levels in NHBE cells, and the addition of VIP to the serosal solution led to an increase in the Isc in a concentration-dependent manner. Expand
Isolation and characterization of new limonoid glycosides from Citrus unshiu peels.
Three limonoid glycosides were isolated from Citrus unshiu peels and their structures were determined based on MS and NMR spectroscopic data, and the location of the sugar moiety was clearly determined by the B/E constant linked scan FABMS method. Expand
Binding and functional affinity of some newly synthesized phenethylamine and phenoxypropanolamine derivatives for their agonistic activity at recombinant human β3‐adrenoceptor
Thirteen new compounds have been evaluated for their potencies and efficacies asβ3‐adrenoceptor agonists on human β3‐ adrenoceptor expressed in COS‐7 and Chinese hamster ovary (CHO) cells using radio ligand binding assay and cyclic AMP (cAMP) accumulation assay. Expand
Pharmacological profiles of a new antiulcer agent, SWR-215.
Results suggest that SWR-215 possesses both durable antisecretory and mucosal protective effects, and is expected to be a useful drug for the treatment of patients with peptic ulcers. Expand
Molecular characterization of pharmacological properties and selectivity of SWR-0315NA for beta3-adrenoceptors.
Results indicate that although SWR-0315NA has lower binding selectivity towards beta-AR subtypes, it is a selective agonist with high intrinsic activity for beta(3)-AR as compared with (-)-isoproterenol. Expand
Rectification effects in ZnO-based transparent self-switching nano-diodes
We report on the fabrication and characterization of the self-switching nano-diodes using zinc oxide films grown on glass substrates for use as transparent rectifiers. Diode-like characteristics wereExpand
Comparison of the binding affinity of some newly synthesized phenylethanolamine and phenoxypropanolamine compounds at recombinant human β‐ and α1‐adrenoceptor subtypes
Six new compounds were evaluated and the binding affinities for human α1‐adrenoceptors expressed in Chinese hamster ovary (CHO) cells were compared using a radioligand‐binding assay to confirm the finding of this manuscript that this phenoxypropanolamine group of β2‐phenyl‐2‐hydroxyethyl ligands could also be used as α1-adrenOceptor ligands. Expand
Fabrication and characterization of antimonide-based composite-channel InAs/AlGaSb HFETs using high-k gate insulators
We report on the fabrication and characterization of antimonide-based composite-channel InAs/AlGaSb HFETs. Antimonide-based compound semiconductors such as those of InAs combined withExpand