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A Randomized, Double-Blind, Placebo-Controlled Dose Range Study of Dexmedetomidine as Adjunctive Therapy for Alcohol Withdrawal*
Objectives:To evaluate dexmedetomidine as adjunctive therapy to lorazepam for severe alcohol withdrawal. Design:Prospective, randomized, double-blind, placebo-controlled trial. Setting:Single center;Expand
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Safety, efficacy, and dosing requirements of bivalirudin in patients with heparin-induced thrombocytopenia.
STUDY OBJECTIVE To evaluate the safety, efficacy, and dosing requirements of bivalirudin in patients with heparin-induced thrombocytopenia (HIT). DESIGN Retrospective cohort study. SETTINGExpand
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Outcomes associated with corticosteroid dosage in critically ill patients with acute exacerbations of chronic obstructive pulmonary disease.
RATIONALE Studies evaluating corticosteroid (CS) dosing for patients hospitalized with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) have largely excluded patients admittedExpand
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Management of extravasation injuries: a focused evaluation of noncytotoxic medications.
Extravasations are common manifestations of iatrogenic injury that occur in patients requiring intravenous delivery of known vesicants. These injuries can contribute substantially to patientExpand
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Reporting Guidelines for Clinical Pharmacokinetic Studies: The ClinPK Statement
AbstractBackground and ObjectiveTransparent reporting of all research is essential for assessing the validity of any study. Reporting guidelines are available and endorsed for many types of researchExpand
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Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition.
BACKGROUND Administration of gastric enteral nutrition (EN) in the intensive care unit (ICU) is commonly impeded by high gastric residual volumes (GRV). This study evaluated gastric emptying inExpand
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Adjunctive dexmedetomidine therapy in the intensive care unit: a retrospective assessment of impact on sedative and analgesic requirements, levels of sedation and analgesia, and ventilatory and
STUDY OBJECTIVE To determine if adjunctive dexmedetomidine therapy in intensive care patients alters requirements for and levels of sedation and analgesia, and to describe hemodynamic and ventilatoryExpand
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Evaluation of a Heparin-Calibrated Antifactor Xa Assay for Measuring the Anticoagulant Effect of Oral Direct Xa Inhibitors
The introduction of oral direct anti-Xa anticoagulants apixaban and rivaroxaban has significantly impacted the treatment and prevention of thromboembolic disease. Clinical scenarios exist in which aExpand
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Stability of phenylephrine hydrochloride injection in polypropylene syringes.
PURPOSE The stability of extemporaneously prepared phenylephrine hydrochloride injection stored in polypropylene syringes was studied. METHODS Dilution of phenylephrine hydrochloride to a nominalExpand
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Proton pump inhibitors and histamine-2 receptor antagonists in the intensive care setting: focus on therapeutic and adverse events
Introduction: Histamine-2 receptor antagonists (H2RA) and proton pump inhibitors (PPI) are frequently used to prevent stress-related mucosal bleeding (SRMB). A paucity of data implicates these agentsExpand
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