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Lysosomal involvement in cell death and cancer.
An overview of the pro- and anti-oncogenic potential of this compartment and how these might be exploited for cancer therapy, with special focus on lysosomal death pathways is provided.
Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology
It is shown that Hsp70 stabilizes lysosomes by binding to an endolysosomal anionic phospholipid bis(monoacylglycero)phosphate (BMP), an essential co-factor for lysOSomal sphingomyelin metabolism.
Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase.
- Nikolaj H. T. Petersen, O. D. Olsen, +15 authors M. Jäättelä
- Biology, MedicineCancer cell
- 9 September 2013
These data identify acid sphingomyelinase (ASM) inhibition as a selective means to destabilize cancer cell lysosomes and identify ASM as an attractive target for cancer therapy.
BAMLET Activates a Lysosomal Cell Death Program in Cancer Cells
- P. Rammer, L. Groth-Pedersen, +8 authors M. Jäättelä
- Medicine, BiologyMolecular Cancer Therapeutics
- 1 January 2010
Data indicate that BAMLET triggers lysosomal cell death pathway in cancer cells, thereby clarifying the ability of α-lactalbumin:oleate complexes to kill highly apoptosis-resistant tumor cells.
Identification of Autophagosome-associated Proteins and Regulators by Quantitative Proteomic Analysis and Genetic Screens*
- J. Dengjel, M. Høyer-Hansen, +16 authors J. Andersen
- Biology, MedicineMolecular & Cellular Proteomics
- 6 February 2012
The combined spatiotemporal proteomic and genetic data sets presented here provide a basis for further characterization of autophagosome biogenesis and cargo selection.
Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression
- A. Jørgensen, P. Magnusson, +10 authors M. Jørgensen
- Psychology, MedicineActa psychiatrica Scandinavica
- 1 February 2016
To investigate the role of hippocampal plasticity in the antidepressant effect of electroconvulsive therapy (ECT), a large number of mice were fitted with a hippocampal “spiking” disorder called “ hippocampus-spiking encephalopathy”.
Human heat shock protein 70 (Hsp70) as a peripheral membrane protein.
- A. K. Mahalka, T. Kirkegaard, Laura T I Jukola, M. Jäättelä, P. Kinnunen
- Chemistry, MedicineBiochimica et biophysica acta
- 1 May 2014
It is suggested that acidic phospholipids induce a transition of SBD into the molten globule state, which may be essential to allow SBD-substrate interaction also within the hydrophobic bilayer interior acyl chain region.
Heat shock protein–based therapy as a potential candidate for treating the sphingolipidoses
- T. Kirkegaard, James Gray, +17 authors F. Platt
- Biology, MedicineScience Translational Medicine
- 7 September 2016
It is demonstrated that recombinant human heat shock protein 70 (HSP70) improves the binding of several sphingolipid-degrading enzymes to their essential cofactor bis(monoacyl)glycerophosphate in vitro.
Accuracy of abdominal auscultation for bowel obstruction.
- B. Breum, B. Rud, T. Kirkegaard, T. Nordentoft
- MedicineWorld journal of gastroenterology
- 14 September 2015
Accuracy and inter-observer agreement was generally low and clinical decisions in patients with possible bowel obstruction should not be based on auscultatory assessment of bowel sounds.
Depletion of Kinesin 5B Affects Lysosomal Distribution and Stability and Induces Peri-Nuclear Accumulation of Autophagosomes in Cancer Cells
- C. M. Cardoso, L. Groth-Pedersen, +5 authors J. Nylandsted
- Biology, MedicinePloS one
- 10 February 2009
The data identify KIF5B as a cancer relevant lysosomal motor protein with additional functions in autophagosome formation, and Surprisingly, Kif5B depletion inhibited the rapamycin-induced accumulation of autophosomes in MCF-7 cells.