T. Kimura

Publications69
h-index14
Citations583
Highly Influential Citations7
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Activation of Proteases in Cerulein‐Induced Pancreatitis
The activation of zymogen proteases and lysosomal enzyme cathepsin B in the pancreas was investigated in cerulein-induced pancreatitis in rats. Acute pancreatitis was induced by two intraperitoneal… Expand
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Effect of endothelin-1 on the development of hemorrhagic pancreatitis in rats.
BACKGROUND It has been hypothesized that microcirculatory disturbance plays an important role in the development of severe pancreatitis. In this study we investigated the effects of exogenous… Expand
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Expression and Diagnostic Evaluation of the Human Tumor–Associated Antigen RCAS1 in Pancreatic Cancer
Introduction Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is one of the membrane molecules expressed on human cancer cells and is presumed to play a protective role for tumor cells… Expand
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Role of Complement Activation and Mast Cell Degranulation in the Pathogenesis of Rapid Intestinal Ischemia/Reperfusion Injury in Rats
The aim of this study is to define the putative role of complement activation and mucosal mast cell (MMC) degranulation in the pathogenesis of rapid ischemia-reperfusion (I/R) injury. We prepared… Expand
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Protective effects of gabexate mesilate on acute pancreatitis induced by tacrolimus (FK-506) in rats in which the pancreas was stimulated by caerulein
We investigated the acute effects of the immunosuppressive agent, tacrolimus (FK-506), on the exocrine pancreas, in rats with or without stimulation of the pancreas, in rats with or without… Expand
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Does stress play a role in the development of severe pancreatitis in rats?
The purpose of this study was to investigate whether stress plays a role, morphologically and enzymatically, in the development of severe pancreatitis in rats. Acute hemorrhagic pancreatitis was… Expand
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Role of Local Pancreatic Blood Flow in Development of Hemorrhagic Pancreatitis Induced by Stress in Rats
Our previous data showed that the pancreatitis induced in rats by cerulein develops into hemorrhagic pancreatitis following water-immersion stress. The present study examined the effects of… Expand
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Effects of H7 and Staurosporine on Cytosolic Free Calcium and Amylase Secretion in Rat Pancreatic Acini
Pretreatment of rat pancreatic acini with 12-0-tetradecanoyl-phorbol-13-acetate (TPA) for 5 or 10 min reduced cytosolic free calcium and amylase secretion stimulated by submaximal concentration (10−6… Expand
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Continuous regional arterial infusion therapy with gabexate mesilate for severe acute pancreatitis.
AIM To evaluate the efficacy of continuous regional arterial infusion therapy (CRAI) with gabexate mesilate and antibiotics for severe acute pancreatitis (SAP). METHODS We conducted a prospective… Expand
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Effects of calcium-channel blockers on cytosolic free calcium and amylase secretion in rat pancreatic acini.
We investigated the effects of verapamil and diltiazem on cytosolic free calcium and amylase secretion in rat pancreatic acini. Verapamil and diltiazem reduced a rise in cytosolic free calcium and… Expand
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