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Damage to the cytoplasmic membrane of Escherichia coli by catechin-copper (II) complexes.
Solid-Aqueous Phase Equilibria of Uranium(VI) under Ambient Conditions
The solubility of uranium(VI) is investigated in the pH range 2.8 to 4.6 in equilibrium with 8.0% and 0.3% C02 partial pressure and in the pH range 3.8 to 7.0 in equilibrium with 0.03% C0 2 partial…
Controlled drug release: new water-soluble prodrugs of an HIV protease inhibitor.
Solubility determination of barely aqueous-soluble organic solids.
- T. Higuchi, F. Shih, T. Kimura, J. H. Rytting
- ChemistryJournal of pharmaceutical sciences
- 1 October 1979
Three approaches to meeting solubility determination of organic molecules having very low solubilities are presented, based on using a large excess of the solid and a highly specific analytical determination of the main component.
Design, synthesis, and biological evaluation of anti-HIV double-drugs. conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor through spontaneously cleavable linkers.
Bactericidal activity of catechin‐copper (II) complexes against Staphylococcus aureus compared with Escherichia coli
- N. Hoshino, T. Kimura, F. Hayakawa, A. Yamaji, T. Ando
- Biology, ChemistryLetters in applied microbiology
- 1 September 2000
The bactericidal activity of catechin‐copper (II) complexes against Staphylococcus aureus compared with Escherichia coli was investigated in relation to the generation of hydrogen peroxide and the…
Luminescence study on solvation of americium(III), curium(III) and several lanthanide(III) ions in nonaqueous and binary mixed solvents
The luminescence lifetimes of An(III) and Ln(III) ions [An=Am and Cm; Ln=Nd, Sm, Eu, Tb and Dy] were measured in dimethyl sulfoxide(DMSO), N,N-dimethylformamide(DMF), methanol(MeOH), water and their…
DNA cleavage reaction and linoleic acid peroxidation induced by tea catechins in the presence of cupric ion.
DNA cleavage activities of (-)-epigallocatechin, (-)-epicatechin, (+)-catechin, and (-)-epigallocatechin gallate with various kinds of metal ions.
- F. Hayakawa, T. Kimura, N. Hoshino, T. Ando
- Chemistry, BiologyBioscience, biotechnology, and biochemistry
- 1 September 1999
Cu(2+) with all the catechins facilitated DNA cleavage, while Ag+ with EGC and EC showed a strong repressive effect, and the other metal ions examined showed little effect.
Small dipeptide-based HIV protease inhibitors containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimic.
- Y. Kiso, H. Matsumoto, S. Mizumoto, T. Kimura, Y. Fujiwara, K. Akaji
- Chemistry, BiologyBiopolymers
A novel class of HIV protease inhibitors containing an unnatural amino acid, (2S, 3S)-3-amino-2-hydroxy-4-phenylbutyric acid, named allophenylnorstatine, with a hydroxymethylcarbonyl (HMC) isostere is designed and synthesized.