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'100 years of peptide synthesis': ligation methods for peptide and protein synthesis with applications to beta-peptide assemblies.
- T. Kimmerlin, D. Seebach
- Chemistry, BiologyThe journal of peptide research : official…
- 5 December 2008
A brief survey of the history of peptide chemistry from Theodore Curtius to Emil Fischer to Bruce Merrifield is presented and couplings involving beta2- and beta3-peptides are described (with experimental details).
Covalent Fluorescence Labeling of His‐Tagged Proteins on the Surface of Living Cells
- Martin Hintersteiner, T. Weidemann, T. Kimmerlin, N. Fi̇li̇z, C. Buehler, M. Auer
- Biology, ChemistryChembiochem : a European journal of chemical…
- 16 June 2008
This work synthesized a trifunctional labeling tag that consists of a fluorophore, a Ni-NTA moiety, and a photoactivatable arylazide that combines the reversible binding of a medium affinity probe with a photoreactive moiety to generate a covalent linkage in the proximity of the tag.
Linear, Peptidase-Resistantβ2/β3-Di- andα/β3-Tetrapeptide Derivatives with Nanomolar Affinities to a Human Somatostatin Receptor, Preliminary Communication
Linear peptidaseresistant B2/B3-Di-and a/B3-tetrapeptide derivatives with nanomolar affinities to a human somatostatin receptor preliminary communication
Investigation of the Interactions of β‐Peptides with DNA Duplexes by Circular Dichroism Spectroscopy
It is impossible, at this stage of the investigation, to make a safe proposal about the actual nature of the interaction of the structures(s) of the complexes, the formation of which is suggested by the CD spectra reported herein.
Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.
The optimization was guided by structure-based design and focused on antibacterial activity in vitro and in vivo, culminating in the discovery of unprecedented substituents able to interact with conserved residues within the ATP-binding site.
Peptide folding induces high and selective affinity of a linear and small beta-peptide to the human somatostatin receptor 4.
- K. Gademann, T. Kimmerlin, D. Hoyer, D. Seebach
- Biology, ChemistryJournal of medicinal chemistry
- 12 July 2001
This work has synthesized an appropriately substituted beta-tetrapeptide derivative to mimic the hormone somatostatin in its binding to the human receptors hsst(1-5), which is known to rest upon a turn containing the amino acid residues Thr, Lys, Trp, and Phe.
Single bead labeling method for combining confocal fluorescence on-bead screening and solution validation of tagged one-bead one-compound libraries.
How we drifted into peptide chemistry and where we have arrived at
Synthesis of3-Peptides and Mixeda/3-Peptides by Thioligation
The so-called native chemical ligation works well with β-peptides, producing larger β3- and α/β3-mixed peptides, including temperature and concentration dependence.
Pharmacokinetic Investigation of a 14C‐Labelled β3/α Tetrapeptide in Rats
The investigated tetrapeptide 3 is a potent and highly specific agonist of the somatostatin receptor hsst4, rendering the results described herein promising for diagnostic and therapeutic applications of β‐peptides.