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Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: effects of selective antagonists and agonists.
TLDR
The results suggest that D1- and D2-like receptors play fundamentally different roles in the relapse process, and either stimulation or blockade of D1 -like receptors appears to be inhibitory with respect to relapse.
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Pharmacological and Environmental Determinants of Relapse to Cocaine-Seeking Behavior
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Dopamine receptor DRD2 genotype and smoking cessation outcome following treatment with bupropion SR
TLDR
In women, individual variability in responsiveness to bupropion-based treatment may be partially due to differences in genetic variants influencing dopamine receptor function, particularly in women who carry both A2 and A1 alleles.
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Effects of intraaccumbens administration of SCH‐23390 on cocaine‐induced locomotion and conditioned place preference
TLDR
It is suggested that stimulation of D1‐like receptors in the NAc is necessary for cocaine‐CPP, but not for cocaine-induced locomotion.
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Comparison of the Antinociceptive and Antirewarding Profiles of Novel Bifunctional Nociceptin Receptor/μ-Opioid Receptor Ligands: Implications for Therapeutic Applications
TLDR
It is suggested that NOPr full-agonist activity is required to modulate opioid-induced reward, whereas a bifunctional Nopr/MOPr partial agonist profile may be suitable as a nonaddicting analgesic.
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Differential effects of intra-accumbens sulpiride on cocaine-induced locomotion and conditioned place preference.
TLDR
It is suggested that D2-like receptors in the NAc and anterior medial caudate-putamen are involved in cocaine-induced locomotion, but not cocaine-conditioned place preference.
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Activities of mixed NOP and μ‐opioid receptor ligands
Compounds that activate both NOP and μ‐opioid receptors might be useful as analgesics and drug abuse medications. Studies were carried out to better understand the biological activity of such…
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Nociceptin/Orphanin FQ Receptor Activation Attenuates Antinociception Induced by Mixed Nociceptin/Orphanin FQ/μ-Opioid Receptor Agonists
TLDR
The hypothesis that activation of NOP receptors can lead to attenuation of MOP receptor-mediated antinociception elicited by mixed NOP/MOP receptor compounds such as buprenorphine, SR16435, and SR16507 is supported.
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SR 16435 [1-(1-(Bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a Novel Mixed Nociceptin/Orphanin FQ/μ-Opioid Receptor Partial Agonist: Analgesic and Rewarding Properties in Mice
TLDR
The mixed NOP/μ-opioid partial agonist SR 16435 exhibited both NOP and μ-OPioid receptor-mediated behaviors, indicating that both opioid and NOP receptors mediate this behavior.
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Rodent models of nicotine reward: What do they tell us about tobacco abuse in humans?
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