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A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression.
TLDR
Quetiapine monotherapy is efficacious and well tolerated for the treatment of bipolar depression and demonstrated statistically significant improvement in Montgomery-Asberg Depression Rating Scale total scores compared with placebo from week 1 onward. Expand
Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression.
TLDR
Olanzapine is more effective than placebo, and combined olanzapine-fluoxetine isMore effective than olanZapine and placebo in the treatment of bipolar I depression without increased risk of developing manic symptoms. Expand
Effectiveness of adjunctive antidepressant treatment for bipolar depression.
TLDR
The use of adjunctive, standard antidepressant medication, as compared with the use of mood stabilizers, was not associated with increased efficacy or with increased risk of treatment-emergent affective switch. Expand
Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression
TLDR
Daily left prefrontal rTMS appears to be safe, well tolerated and may alleviate depression. Expand
Brain activity during transient sadness and happiness in healthy women.
TLDR
Transient sadness and happiness in healthy volunteer women are accompanied by significant changes in regional brain activity in the limbic system, as well as other brain regions, which have implications for understanding the neural substrates of both normal and pathological emotion. Expand
Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD)
TLDR
The methodology used for the selection and certification of the clinical treatment centers, training study personnel, the general approach to clinical management, and the sequential treatment strategies offered in the STEP-BD standard and randomized care pathways for bipolar depression and relapse prevention are reviewed. Expand
Mood Disorders in the Medically Ill: Scientific Review and Recommendations
TLDR
A growing body of evidence suggests that biological mechanisms underlie a bidirectional link between mood disorders and many medical illnesses and there is evidence to suggest that mood disorders affect the course of medical illnesses. Expand
Impaired recognition of facial emotion in mania.
TLDR
Impaired recognition of fear and disgust, with relatively preserved recognition of other basic emotions, contrasts with findings for depression and is consistent with a mood-congruent positive bias. Expand
Temperamental commonalities and differences in euthymic mood disorder patients, creative controls, and healthy controls.
TLDR
The prominent BP-CC overlap suggests underlying neurobiological commonalities between people with mood disorders and individuals involved in creative disciplines, consistent with the notion of a temperamental contribution to enhanced creativity in individuals with bipolar disorders. Expand
The Texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorder.
TLDR
These algorithms for the treatment of BDI represent the recommendations based on the most recent evidence available and are meant to provide a framework for clinical decision making, not to replace clinical judgment. Expand
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