A randomized, double-blind, placebo-controlled trial of quetiapine in the treatment of bipolar I or II depression.
Quetiapine monotherapy is efficacious and well tolerated for the treatment of bipolar depression and demonstrated statistically significant improvement in Montgomery-Asberg Depression Rating Scale total scores compared with placebo from week 1 onward.
Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression.
Olanzapine is more effective than placebo, and combined olanzapine-fluoxetine isMore effective than olanZapine and placebo in the treatment of bipolar I depression without increased risk of developing manic symptoms.
Brain activity during transient sadness and happiness in healthy women.
- M. George, T. Ketter, P. Parekh, B. Horwitz, P. Herscovitch, R. Post
- Psychology, MedicineAmerican Journal of Psychiatry
- 1 March 1995
Transient sadness and happiness in healthy volunteer women are accompanied by significant changes in regional brain activity in the limbic system, as well as other brain regions, which have implications for understanding the neural substrates of both normal and pathological emotion.
Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression
Daily left prefrontal rTMS appears to be safe, well tolerated and may alleviate depression.
Rationale, design, and methods of the systematic treatment enhancement program for bipolar disorder (STEP-BD)
Effectiveness of adjunctive antidepressant treatment for bipolar depression.
The use of adjunctive, standard antidepressant medication, as compared with the use of mood stabilizers, was not associated with increased efficacy or with increased risk of treatment-emergent affective switch.
Mood Disorders in the Medically Ill: Scientific Review and Recommendations
Impaired recognition of facial emotion in mania.
Impaired recognition of fear and disgust, with relatively preserved recognition of other basic emotions, contrasts with findings for depression and is consistent with a mood-congruent positive bias.
Temperamental commonalities and differences in euthymic mood disorder patients, creative controls, and healthy controls.
Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission.
The role of the mu-opioid receptor system in the physiological regulation of affective experiences in humans is confirmed and dynamic changes in mu-OPioid neurotransmission in response to an experimentally induced negative affective state are demonstrated.