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A central role for inflammation in the pathogenesis of diabetic retinopathy
- A. Joussen, V. Poulaki, A. Adamis
- Medicine, BiologyFASEB journal : official publication of the…
- 1 September 2004
It is shown that chronic, low‐grade subclinical inflammation is responsible for many of the signature vascular lesions of diabetic retinopathy, highlighting the central and causal role of adherent leukocytes in the pathogenesis of diabetes.
Contributions of Inflammatory Processes to the Development of the Early Stages of Diabetic Retinopathy
- T. Kern
- Medicine, BiologyExperimental diabetes research
- 30 September 2007
This new hypothesis offers new insight into the pathogenesis of diabetic retinopathy, and offers novel targets to inhibit the ocular disease.
Inflammation in diabetic retinopathy
The Ins2Akita mouse as a model of early retinal complications in diabetes.
- A. Barber, D. Antonetti, S. Bronson
- Biology, MedicineInvestigative ophthalmology & visual science
- 1 June 2005
The retinas of heterozygous male Ins2(Akita) mice exhibit vascular, neural, and glial abnormalities generally consistent with clinical observations and other animal models of diabetes.
Amelioration of Vascular Dysfunctions in Diabetic Rats by an Oral PKC β Inhibitor
When administered orally, LY333531 ameliorated the glomerular filtration rate, albumin excretion rate, and retinal circulation in diabetic rats in a dose-responsive manner, in parallel with its inhibition of PKC activities.
Characterization of the Mechanism for the Chronic Activation of Diacylglycerol-Protein Kinase C Pathway in Diabetes and Hypergalactosemia
- P. Xia, T. Inoguchi, T. Kern, R. Engerman, P. Oates, G. King
- Medicine, BiologyDiabetes
- 1 September 1994
Findings have clearly demonstrated a possible common biochemical mechanism by which hyperglycemia and hypergalactosemia can chronically activate the DAG-PKC pathway in the vasculature and could be a possible explanation for the development of diabetic vascular complications.
Update on animal models of diabetic retinopathy: from molecular approaches to mice and higher mammals
- Remya Robinson, V. Barathi, S. S. Chaurasia, T. Wong, T. Kern
- Biology, MedicineDisease Models & Mechanisms
- 1 July 2012
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and one of the major causes of blindness worldwide. The pathogenesis of DR has been investigated using several…
Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy.
Findings indicate that diabetes and galactosemia lead to accelerated death in situ of both retinal pericytes and endothelial cells; the event is specific for vascular cells; it precedes histological evidence of retinopathy; and it can be induced by isolated hyperhexosemia.
Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation.
- Mariana G Rosca, T. Mustaţă, M. Weiss
- Biology, ChemistryAmerican journal of physiology. Renal physiology
- 1 August 2005
Posttranslational modifications of mitochondrial proteins by MGO may represent pathogenic events leading to mitochondria-induced oxidative stress in the kidney in chronic diabetes.
Progression of Incipient Diabetic Retinopathy During Good Glycemic Control
The results indicate that retinopathy may be preventable but tends to resist arrest even in its incipient stages, before more than the first few aneurysms have appeared.