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G Protein-Coupled Receptor Allosterism and Complexing
- A. Christopoulos, T. Kenakin
- BiologyPharmacological Reviews
- 1 June 2002
TLDR
Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules
- C. Briscoe, A. Peat, S. Jenkinson
- Biology, MedicineBritish journal of pharmacology
- 1 July 2006
TLDR
Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery
- T. Kenakin, L. Miller
- BiologyPharmacological Reviews
- 1 June 2010
TLDR
A simple method for quantifying functional selectivity and agonist bias.
- T. Kenakin, C. Watson, Vanessa M Muniz-Medina, A. Christopoulos, Steven J Novick
- BiologyACS chemical neuroscience
- 21 March 2012
TLDR
International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology
- R. Neubig, M. Spedding, T. Kenakin, A. Christopoulos
- Chemistry, BiologyPharmacological Reviews
- 1 December 2003
The recommendations that follow have been updated from the proposals of a Technical Subcommittee set up by the International Union of Pharmacology Committee on Receptor Nomenclature and Drug…
Signalling bias in new drug discovery: detection, quantification and therapeutic impact
- T. Kenakin, A. Christopoulos
- BiologyNature Reviews Drug Discovery
- 1 March 2013
TLDR
Agonist-receptor efficacy. II. Agonist trafficking of receptor signals.
- T. Kenakin
- BiologyTrends in pharmacological sciences
- 1 July 1995
The CCR5 Receptor-Based Mechanism of Action of 873140, a Potent Allosteric Noncompetitive HIV Entry Inhibitors⃞
- C. Watson, S. Jenkinson, W. Kazmierski, T. Kenakin
- Chemistry, BiologyMolecular Pharmacology
- 1 April 2005
TLDR
Inverse, protean, and ligand‐selective agonism: matters of receptor conformation
- T. Kenakin
- BiologyFASEB journal : official publication of the…
- 1 March 2001
TLDR
Ligand-selective receptor conformations revisited: the promise and the problem.
- T. Kenakin
- BiologyTrends in pharmacological sciences
- 1 July 2003
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