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Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivity.
TLDR
The findings suggest that the neural basis of disordered language in autism entails a lower degree of information integration and synchronization across the large-scale cortical network for language processing.
Brain Activation Modulated by Sentence Comprehension
TLDR
The comprehension of visually presented sentences produces brain activation that increases with the linguistic complexity of the sentence, and the amount of neural activity that a given cognitive process engenders is dependent on the computational demand that the task imposes.
Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry.
TLDR
The brain activation of a group of high-functioning autistic participants was measured using functional magnetic resonance imaging during the performance of a Tower of London task, in comparison with a control group matched with respect to intelligent quotient, age, and gender to suggest underconnectivity in the group with autism.
Functional connectivity in a baseline resting-state network in autism
TLDR
The results indicate that both groups have a resting-state network that is very similar both in volume and in organization, but in autism this network is much more loosely connected.
fMRI investigation of working memory for faces in autism: visual coding and underconnectivity with frontal areas.
TLDR
Previous findings of abnormal face perception in autism are extended by demonstrating that the abnormalities are embedded in an abnormal cortical network that manages to perform the working memory task proficiently, using a visually oriented, asocial processing style that minimizes reliance on prefrontal areas.
Graded Functional Activation in the Visuospatial System with the Amount of Task Demand
TLDR
The data suggest that the amount of activation in the various cortical regions that support visuospatial processing is related to the amount, as well as to the type, of computational demand.
A developmental study of the structural integrity of white matter in autism
TLDR
The findings suggest that reductions in the structural integrity of white matter in autism persist into adulthood, and may underlie the behavioral pattern observed in autism, as well as findings of reduced functional connectivity in functional magnetic resonance imaging signal between activating cortical areas.
Sentence comprehension in autism: thinking in pictures with decreased functional connectivity.
TLDR
The findings provide further evidence of underintegration of language and imagery in autism (and hence expand the understanding of underconnectivity) but also show that people with autism are more reliant on visualization to support language comprehension.
The neural bases of sentence comprehension: a fMRI examination of syntactic and lexical processing.
TLDR
The results suggest that many processes in sentence comprehension involve multiple brain regions, and that many brain regions contribute to more than one comprehension process, suggesting that the language network consists of brain areas which each have multiple relative specializations and which engage in extensive interarea collaborations.
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