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Evolution of genes and genomes on the Drosophila phylogeny
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genomeExpand
Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome
In fruit fly research, chromosomal deletions are indispensable tools for mapping mutations, characterizing alleles and identifying interacting loci. Most widely used deletions were generated byExpand
Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE
Drosophila model organism Encyclopedia of DNA Elements (modENCODE) project is comprehensively mapping transcripts, histone modifications, chromosomal proteins, transcription factors, replication proteins and intermediates, and nucleosome properties across a developmental time course and in multiple cell lines. Expand
The Developmental Transcriptome of Drosophila melanogaster
Drosophila melanogaster is one of the most well studied genetic model organisms, nonetheless its genome still contains unannotated coding and non-coding genes, transcripts, exons, and RNA editingExpand
FlyBase 2.0: the next generation
We describe major new features and functionalities of the FlyBase 2.0 site and how they support the use of Drosophila as a model organism for biological discovery and translational research. Expand
Diversity and dynamics of the Drosophila transcriptome
Animal transcriptomes are dynamic, with each cell type, tissue and organ system expressing an ensemble of transcript isoforms that give rise to substantial diversity. Here we have identified newExpand
Hox genes and the evolution of the arthropod body plan 1
SUMMARY In recent years researchers have analyzed the expression patterns of the Hox genes in a multitude of arthropod species, with the hope of understanding the mechanisms at work in the evolutionExpand
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures
Sequencing of multiple related species followed by comparative genomics analysis constitutes a powerful approach for the systematic understanding of any genome. Here, we use the genomes of 12Expand
The ribosomal protein genes and Minute loci of Drosophila melanogaster
BackgroundMutations in genes encoding ribosomal proteins (RPs) have been shown to cause an array of cellular and developmental defects in a variety of organisms. In Drosophila melanogaster,Expand
Genome-wide analysis of promoter architecture in Drosophila melanogaster.
Core promoters are critical regions for gene regulation in higher eukaryotes. However, the boundaries of promoter regions, the relative rates of initiation at the transcription start sites (TSSs)Expand