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A novel chemometric strategy for the estimation of extra virgin olive oil adulteration with edible oils
A useful procedure for the qualitative and quantitative determination of vegetable oils (canola, hazelnut, pomace and high linoleic/oleic sunflower) as adulterants in commercial samples of extraExpand
Monitoring of fatty acid composition in virgin olive oil by Fourier transformed infrared spectroscopy coupled with partial least squares
Abstract A rapid Fourier transformed infrared (FTIR) attenuated total reflectance (ATR) spectroscopic method was applied to the determination of fatty acid (FA) profile and peroxide value (PV) ofExpand
A new principal component analysis-based approach for testing "similarity" of drug dissolution profiles.
TLDR
Comparisons between the area enclosed by the confidence ellipses of the weighed scores plot and the region obtained from the bootstrap-calculated acceptable values of the corresponding f2 tests suggested that PCA-CR represents, in general, a more discriminating standard. Expand
DEVELOPMENT AND VALIDATION OF A HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF BROMHEXINE, CHLORPHENIRAMINE, PARACETAMOL, AND PSEUDOEPHEDRINE IN THEIR COMBINED COLD MEDICINE FORMULATIONS
A simple and efficient liquid chromatographic method has been developed and validated for the simultaneous determination of bromhexine, chlorpheniramine, paracetamol, and pseudoephedrine in commonExpand
Simultaneous determination of amiloride hydrochloride and hydrochlorothiazide in synthetic samples and pharmaceutical formulations by multivariate analysis of spectrophotometric data.
TLDR
Partial least squares (PLS-1) analysis of electronic absorption spectral data allowed the rapid and accurate resolution of mixtures in which the analyte ratios were approximately 10:1, without the need of a previous separation step and without interference from other sample constituents. Expand
PCA-CR analysis of dissolution profiles. A chemometric approach to probe the polymorphic form of the active pharmaceutical ingredient in a drug product.
TLDR
PCA-CR was able to differentiate among the three crystalline polymorphs of FUR and to confirm the presence of polymorph I in the test sample, with 99% statistical confidence, and may be considered a complementary and useful tool for probing the polymorphic form present in a pharmaceutical formulation. Expand
Studies on the intramolecular oxa-Pictet–Spengler rearrangement of 5-aryl-1,3-dioxolanes to 4-hydroxy-isochromans
Abstract The success and stereochemical outcome of the TiCl 4 -promoted oxa-Pictet–Spengler cyclization of 5-aryl-1,3-dioxolanes to produce 1,3-disubstituted-4-hydroxy-isochromans, is influenced byExpand
The quest for quinine: those who won the battles and those who won the war.
TLDR
The recently disclosed syntheses of quinine testify in a remarkable manner the huge progress made by organic synthesis during the last three decades since the first series of partially controlled syntheses by the group of Uskokovic. Expand
Synthesis and preliminary evaluation of 3-thiocyanato-1H-indoles as potential anticancer agents.
TLDR
Results suggest that the indole-3-thiocyanate motif can be suitably decorated to afford highly cytotoxic compounds and that the substituted indole can be employed as a useful scaffold toward more potent compounds. Expand
Pharmaceutical impurities and degradation products: uses and applications of NMR techniques.
TLDR
The applications of NMR spectroscopy and its hyphenated derivate techniques to the study of a wide range pharmaceutical impurities are discussed and contribute to the goal of making better and safer medicines. Expand
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