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Direct binding between two PDZ domain proteins Canoe and ZO-1 and their roles in regulation of the Jun N-terminal kinase pathway in Drosophila morphogenesis
- K. Takahashi, T. Matsuo, T. Katsube, R. Ueda, D. Yamamoto
- Biology, Medicine
- Mechanisms of Development
- 1 November 1998
During Drosophila embryogenesis, the ventral epidermis dorsally expands and the left and right epithelial sheets meet and fuse along the dorsal midline. For this dorsal closure to occur, two PDZ… Expand
Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7.
UT-7 is a human leukemic cell line capable of growing in interleukin-3 (IL-3), granulocyte/macrophage colony-stimulating factor (GM-CSF), or erythropoietin (Epo) (Komatsu et al, Cancer Res 51:341,… Expand
Cortactin Associates with the Cell-Cell Junction Protein ZO-1 in both Drosophila and Mouse*
- T. Katsube, M. Takahisa, R. Ueda, N. Hashimoto, M. Kobayashi, S. Togashi
- Medicine, Biology
- The Journal of Biological Chemistry
- 6 November 1998
Cortactin is an actin filament-binding protein localizing at cortical regions of cells and a prominent substrate for Src family protein-tyrosine kinases in response to multiple extracellular stimuli.… Expand
Most hydrogen peroxide-induced histone H2AX phosphorylation is mediated by ATR and is not dependent on DNA double-strand breaks.
The nuclear foci of phosphorylated histone H2AX (γH2AX) are frequently used as a marker for DNA double-strand breaks (DSBs) following ionizing radiation (IR). However, recent studies reported that… Expand
Involvement of Illegitimate V(D)J Recombination or Microhomology-Mediated Nonhomologous End-Joining in the Formation of Intragenic Deletions of the Notch1 Gene in Mouse Thymic Lymphomas
Deregulated V(D)J recombination-mediated chromosomal rearrangements are implicated in the etiology of B- and T-cell lymphomagenesis. We describe three pathways for the formation of 5′-deletions of… Expand
Nitric oxide attenuates hydrogen peroxide-induced barrier disruption and protein tyrosine phosphorylation in monolayers of intestinal epithelial cell.
The intestinal epithelium provides a barrier to the transport of harmful luminal molecules into the systemic circulation. A dysfunctional epithelial barrier is closely associated with the… Expand
Radiation-induced deletions in the 5' end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas.
Notch1 protein is a transmembrane receptor that directs various cell fate decisions. Active forms of Notch1 consisting of a transmembrane domain and an intracellular domain (Notch1TM) or only an… Expand
p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway
p27Kip1 (p27) is a cyclin-CDK inhibitor and negative regulator of cell proliferation. p27 also controls other cellular processes including migration and cytoplasmic p27 can act as an oncogene.… Expand
Differences in sensitivity to DNA-damaging Agents between XRCC4- and Artemis-deficient human cells.
- T. Katsube, M. Mori, H. Tsuji, T. Shiomi, Naoko Shiomi, M. Onoda
- Medicine, Biology
- Journal of radiation research
- 1 July 2011
Non-homologous end-joining (NHEJ) is the predominant pathway for the repair of DNA double-strand breaks (DSBs) in human cells. XRCC4 is indispensable to NHEJ and functions together with DNA ligase IV… Expand
Filamentous actin binding ability of cortactin isoforms is responsible for their cell-cell junctional localization in epithelial cells.
- T. Katsube, S. Togashi, N. Hashimoto, T. Ogiu, H. Tsuji
- Biology, Medicine
- Archives of biochemistry and biophysics
- 1 July 2004
Cortactin is an F-actin binding protein that contributes to cytoskeleton remodelling. We identified five isoforms of mouse cortactin that differ in the number of tandem 37-amino acid repeats, named… Expand