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Changes in Prolyl Endopeptidase During Maturation of Rat Brain and Hydrolysis of Substance P by the Purified Enzyme
: We determined changes in prolyl endopeptidase activity in developing rat brain. A new and highly sensitive fluorogenic substrate, 7‐(succinyl‐Gly‐Pro)‐4‐methylcoumarinamide, was used forExpand
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Critical Role for the 310 Helix Region of p57Kip2 in Cyclin-dependent Kinase 2 Inhibition and Growth Suppression*
Although crystal structural analysis of cyclin A/cyclin-dependent kinase 2 (Cdk2)/p27 (Russo, A. A., Jeffrey, P. D., Pattern, A. K., Massague, J., and Pavletich, N. P. (1996) Nature 382, 325–331) hasExpand
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Aromatic L-amino acid decarboxylase activity in central and peripheral tissues and serum of rats with L-DOPA and L-5-hydroxytryptophan as substrates.
Abstract This paper describes the distribution of aromatic l -amino acid decarboxylase (AADC) activities in seventeen tissues (eleven peripheral and six brain tissues) of rats, using both l -DOPA andExpand
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Binding profile of SM-9018, a novel antipsychotic candidate.
The present study employed various receptor-binding assays to clarify the biochemical characteristics of SM-9018. SM-9018 possessed very high affinity for 5-HT2, D2 and 5-HT1A receptors (Ki = 0.61,Expand
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Production of fosfomycin (phosphonomycin) by Pseudomonas syringae.
In recent years, it has become to be recognized that bacteria can produce antibiotics of wide structural diversity, some of which are known also as the products of Actinomycetales1~5) Here we reportExpand
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Possible regulation of 5-fluorouracil-induced neuro- and oral toxicities by two biochemical modulators consisting of S-1, a new oral formulation of 5-fluorouracil.
S-1 is a new oral formulation of 5-fluorouracil (5-FU) containing 1 M tegafur and 0.4 M 5-chloro-2,4-dihydroxypyridine (CDHP) and 1 M potassium oxonate (Oxo). It has been reported to have a highExpand
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Rapid chromatographic purification of dipeptidyl peptidase IV in human submaxillary gland.
Pure dipeptidyl peptidase IV (X-prolyl dipeptidyl aminopeptidase), which did not contain aminopeptidase activity at all, was rapidly prepared from the human submaxillary gland by chromatography withExpand
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The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma.
We reported previously that tumor cells isolated from metastases of the in vitro transformed squamous cell carcinoma line Pam 212 exhibit an elevation in constitutive production of proinflmmatoryExpand
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Norfloxacin resistance in a clinical isolate of Escherichia coli.
Analysis of DNA gyrase supercoiling and of norfloxacin uptake in Escherichia coli GN14176, a moderately norfloxacin-resistant clinical isolate, indicated that resistance was associated with both anExpand
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Antiherpesvirus Activities of (1′S,2′R)-9-{[1′,2′-Bis(hydroxymethyl)cycloprop-1′-yl]methyl}guanine (A-5021) in Cell Culture
ABSTRACT Antiherpetic activity of (1′S,2′R)-9-{[1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl}guanine (A-5021) was compared with those of acyclovir (ACV) and penciclovir (PCV) in cell cultures. In aExpand
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