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Organizer-Like Reticular Stromal Cell Layer Common to Adult Secondary Lymphoid Organs1
Mesenchymal stromal cells are crucial components of secondary lymphoid organs (SLOs). Organogenesis of SLOs involves specialized stromal cells, designated lymphoid tissue organizer (LTo) in theExpand
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Lymph Node Fibroblastic Reticular Cells Construct the Stromal Reticulum via Contact with Lymphocytes
The sophisticated microarchitecture of the lymph node, which is largely supported by a reticular network of fibroblastic reticular cells (FRCs) and extracellular matrix, is essential for immuneExpand
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The Balance Between Pax5 and Id2 Activities Is the Key to AID Gene Expression
Pax5 activity is enhanced in activated B cells and is essential for class switch recombination (CSR). We show that inhibitor of differentiation (Id)2 suppresses CSR by repressing the gene expressionExpand
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A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells.
For efficient adaptive immunity, the lymph nodes (LNs) are equipped with a strategically organized microarchitecture, which is largely supported by the reticular network (RN). The RN can be clearlyExpand
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Transcription-Coupled Events Associating with Immunoglobulin Switch Region Chromatin
Class switch recombination (CSR) at the antibody immunoglobulin locus is regulated by germline transcription (GLT)–coupled modifications in the accessibility of the switch region, where CSR takesExpand
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Roles of p-ERM and Rho–ROCK signaling in lymphocyte polarity and uropod formation
Front–rear asymmetry in motile cells is crucial for efficient directional movement. The uropod in migrating lymphocytes is a posterior protrusion in which several proteins, including CD44 andExpand
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DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
To migrate efficiently through the interstitium, dendritic cells (DCs) constantly adapt their shape to the given structure of the extracellular matrix and follow the path of least resistance. It isExpand
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Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes
The regulation of lymphocyte adhesion and migration plays crucial roles in lymphocyte trafficking during immunosurveillance. However, our understanding of the intracellular signalling that regulatesExpand
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Essential role of Id2 in negative regulation of IgE class switching
Serum concentrations of immunoglobulin E (IgE) in normal circumstances are kept much lower than those of other Ig isotypes to avoid allergic reactions. B cells lacking Id2 have increased E2AExpand
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Marginal reticular cells: a stromal subset directly descended from the lymphoid tissue organizer
  • T. Katakai
  • Biology, Medicine
  • Front. Immun.
  • 12 July 2012
The architecture of secondary lymphoid organs (SLOs) is supported by several non-hematopoietic stromal cells. Currently it is established that two distinct stromal subsets, follicular dendritic cellsExpand
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