Organizer-Like Reticular Stromal Cell Layer Common to Adult Secondary Lymphoid Organs1
- T. Katakai, H. Suto, A. Shimizu
- Biology, MedicineJournal of Immunology
- 1 November 2008
A comprehensive view of the stromal composition and architecture of SLOs is presented, finding that MRCs were commonly observed at particular sites in various SLOs even in Rag2−/− mice, but were not found in ectopic lymphoid tissues, suggesting that MECs are a developmentally determined element.
Lymph Node Fibroblastic Reticular Cells Construct the Stromal Reticulum via Contact with Lymphocytes
- T. Katakai, T. Hara, M. Sugai, H. Gonda, A. Shimizu
- BiologyJournal of Experimental Medicine
- 20 September 2004
Signals from lymphocytes induce FRCs to form the network that supports the movement and interactions of immune effectors within the lymph node, which is suggested to be a nuclear factor-κB (RelA)–dependent manner.
The Balance Between Pax5 and Id2 Activities Is the Key to AID Gene Expression
- H. Gonda, M. Sugai, A. Shimizu
- BiologyJournal of Experimental Medicine
- 3 November 2003
It is shown that inhibitor of differentiation (Id)2 suppresses CSR by repressing the gene expression of activation-induced cytidine deaminase (AID), which has been shown to be indispensable for CSR.
A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells and B cells.
- T. Katakai, T. Hara, Jong-Hwan Lee, H. Gonda, M. Sugai, A. Shimizu
- BiologyInternational Immunology
- 28 June 2004
New insights are provided into how the LN stromal reticulum works as a specialized 'immuno-platform' for tissue compartmentalization and the immune response.
Transcription-Coupled Events Associating with Immunoglobulin Switch Region Chromatin
- Y. Nambu, M. Sugai, A. Shimizu
- BiologyScience
- 19 December 2003
The results indicate an important role of GLT in the regulation of chromatin accessibility, strongly suggesting that the target of AID is chromatin DNA.
Roles of p-ERM and Rho–ROCK signaling in lymphocyte polarity and uropod formation
- Jong-Hwan Lee, T. Katakai, T. Hara, H. Gonda, M. Sugai, A. Shimizu
- BiologyJournal of Cell Biology
- 25 October 2004
Phosphorylated ERM has a potential function in establishing plasma membrane “posteriority” in the induction of the uropod in T lymphocytes and is associated with constitutively active Q63L RhoA in the rear part of the cells.
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
- Yosuke Harada, Yoshihiko Tanaka, Y. Fukui
- BiologyBlood
- 10 May 2012
It is shown that DOCK8 is a Cdc42-specific guanine nucleotide exchange factor that is critical for interstitial DC migration, and that in the absence of Dock8, DCs failed to accumulate in the lymph node parenchyma for T-cell priming.
Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes
- K. Katagiri, T. Katakai, Yukihiko Ebisuno, Y. Ueda, T. Okada, T. Kinashi
- BiologyEMBO Journal
- 6 May 2009
It is shown that the Ste20‐like kinase Mst1 plays crucial roles in lymphocyte trafficking in vivo and is a key enzyme involved in lymphocytes entry and interstitial migration.
CRTAM determines the CD4+ cytotoxic T lymphocyte lineage
- A. Takeuchi, Mohamed Badr, T. Saito
- BiologyJournal of Experimental Medicine
- 11 January 2016
It is demonstrated that CRTAM identifies CD4 T cells with cytotoxic function, and new insights into CD4+CTL development are presented.
Essential role of Id2 in negative regulation of IgE class switching
- M. Sugai, H. Gonda, T. Kusunoki, T. Katakai, Y. Yokota, A. Shimizu
- Biology, MedicineNature Immunology
- 2003
The results provide evidence for the inhibitory and selective role of Id2 in IgE CSR in response to TGF-β1 and suggest that Id2 might act as molecular safeguard to suppress IgECSR to prevent serious complications such as allergic hypersensitivity during the normal course of immune responses.
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