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AS-4370, a new gastrokinetic agent, enhances upper gastrointestinal motor activity in conscious dogs.
The effects of AS-4370 [4-amino-5-chloro-2-ethoxy-N-(4-(4-fluorobenzyl)-2 morpholinyl)methyl)benzamide citrate] on gastrointestinal (GI) motor activity were compared with those of cisapride andExpand
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Relationships Between Plasma Concentrations of Diphenylhydantoin, Phenobarbital, Carbamazepine, and 3‐Sulfamoylmethyl‐1,2‐Benzisoxazole (AD‐810), a New Anticonvulsant Agent, and Their Anticonvulsant
Summary: The relationships between plasma concentrations of diphenylhydantoin (DPH), phenobarbital (PB), carbamazepine (CBZ), and 3‐sulfamoylmethyl‐l,2‐benzisoxazole (AD‐810), a new anticonvulsantExpand
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AS-4370, a novel gastrokinetic agent free of dopamine D2 receptor antagonist properties.
The gastrokinetic effects of AS-4370, 4-amino-5-chloro-2-ethoxy-N-([4-(4-fluorobenzyl)-2-morpholinyl] methyl) benzamide citrate, were compared with those of metoclopramide in experimental animals. InExpand
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Pharmacological profile of AD-5423, a novel antipsychotic with both potent dopamine-D2 and serotonin-S2 antagonist properties.
The pharmacological properties of AD-5423 [2-(4-ethyl-1-piper-azinyl)-4- (4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine] were studied in biochemical and behavioral tests. In vitro,Expand
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Evidence for a synergistic interaction between phenytoin and phenobarbital in experimental animals.
Combined anticonvulsant effects of phenytoin and phenobarbital in mice and rabbits were studied using the isobolographic method which was based on the plasma concentrations of these drugs.Expand
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Antiplatelet mechanisms of TA-993 and its metabolite MB3 in ADP-induced platelet aggregation.
We investigated the antiplatelet mechanisms of TA-993 [(-)-cis-3-acetoxy-5-(2-(dimethylamino)ethyl)-2, 3-dihydro-8-methyl-2-(4-methylphenyl)-1,5-benzothiazepin-4(5H)-one maleate] and its metaboliteExpand
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Protective effect of prostaglandins D2, E1 and I2 against cerebral hypoxia/anoxia in mice
Summary1.The protective effect of prostaglandins (PGs) against cerebral hypoxia/anoxia was investigated with a variety of experimental models in relation to their CNS depressant effects in mice.Expand
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General pharmacology of the novel antiepileptic compound zonisamide. 1st communication: effects on central nervous system.
The effects of 1,2-benzisoxazole-3-methanesulfonamide (zonisamide, AD-810, CI-912), an antiepileptic compound, on the central nervous system were compared with those of carbamazepine andExpand
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