Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled,…
- J. Howard, K. Utsugisawa, H. Vu
- MedicineLancet Neurology
- 1 December 2017
Pericyte-derived Glial Cell Line-derived Neurotrophic Factor Increase the Expression of Claudin-5 in the Blood–brain Barrier and the Blood-nerve Barrier
- F. Shimizu, Y. Sano, T. Kanda
- BiologyNeurochemical Research
- 1 February 2012
Results indicate that the regulation of GDNF secreted from pericytes may be a novel therapeutic strategy to modify the BBB or BNB functions and promote brain or peripheral nerve regeneration.
A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport
- N. Wevers, Dhanesh Kasi, B. Obermeier
- BiologyFluids and Barriers of the CNS
- 31 August 2018
This in vitro model shows sufficient barrier function to study the passage of large molecules and is sensitive to differences in antibody penetration, which could support discovery and engineering of BBB-shuttle technologies.
Morphological changes in unmyelinated nerve fibres in the sural nerve with age.
- T. Kanda, H. Tsukagoshi, M. Oda, K. Miyamoto, H. Tanabe
- BiologyBrain : a journal of neurology
- 1 February 1991
The age-dependent changes in unmyelinated nerve fibres thus mainly consist of an increased production of processes by Schwann cells in the absence of cell multiplication, which is considered to be useful and superior to the conventional assessment of un myelinated axon density and diameter distribution.
Advanced glycation end-products disrupt the blood–brain barrier by stimulating the release of transforming growth factor–β by pericytes and vascular endothelial growth factor and matrix…
- F. Shimizu, Y. Sano, Osamu Tominaga, T. Maeda, M. Abe, T. Kanda
- BiologyNeurobiology of Aging
- 1 July 2013
Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica
- F. Shimizu, Kristin L Schaller, J. Bennett
- BiologyScience Translational Medicine
- 5 July 2017
These findings suggest that glucose-regulated protein 78–targeted antibodies could be instigating blood-brain barrier breakdown and development of hallmark anti–aquaporin-4 autoantibody pathology and the application of these antibodies could help open up the blood- brain barrier for transit of treatments for many central nervous system diseases.
Peripheral Nerve pericytes originating from the blood–nerve barrier expresses tight junctional molecules and transporters as barrier‐forming cells
- F. Shimizu, Y. Sano, T. Kanda
- BiologyJournal of Cellular Physiology
- 1 November 2008
It is considered that occludin localized at the cell–cell boundaries among the pericytes might mechanically stabilize the microvessels of the BNB and the blood–brain barrier.
Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy
- Y. Ichimura, T. Matsushita, M. Fujimoto
- Medicine, BiologyAnnals of the Rheumatic Diseases
- 17 January 2012
While less common than in juvenile IIM, anti-NXP2 Ab was found inAdult IIM and may be associated with adult IIM with malignancy.
Distinct Roles of IL-23 and IL-17 in the Development of Psoriasis-Like Lesions in a Mouse Model
- K. Nakajima, T. Kanda, S. Sano
- Biology, MedicineJournal of Immunology
- 1 April 2011
The K5.Stat3C transgenic mice system provides a useful mouse model for psoriasis and demonstrates distinct roles for IL-23 and IL-17.
Effects of neuromyelitis optica–IgG at the blood–brain barrier in vitro
- Y. Takeshita, B. Obermeier, R. Ransohoff
- Biology, MedicineNeurology: Neuroimmunology & Neuroinflammation
- 19 December 2016
The results indicate that NMO-IgG induces IL-6 production by AQP4-positive astrocytes and that IL- 6 signaling to EC decreases barrier function, increases chemokine production, and enhances leukocyte transmigration under flow.
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