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Specific and efficient transduction of Cochlear inner hair cells with recombinant adeno-associated virus type 3 vector.
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Interleukin-6 directly influences proliferation and invasion potential of head and neck cancer cells
TLDR
The results suggest that IL-6 can directly influence cell proliferation and the invasion potential as the first step of tumor metastasis.
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Epigenetic Inactivation of Galanin Receptor 1 in Head and Neck Cancer
TLDR
Frequent promoter hypermethylation, gene silencing, association with prognosis, and growth suppression after reexpression support the hypothesis that GALR1 is a tumor suppressor gene in HNSCC.
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Galanin and galanin receptor type 1 suppress proliferation in squamous carcinoma cells: activation of the extracellular signal regulated kinase pathway and induction of cyclin-dependent kinase…
TLDR
The results implicate GALR1, a Gi protein-coupled receptor, as a tumor suppressor gene that inhibits cell proliferation via ERK1/2 activation and also inhibit colony formation and tumor growth in vivo.
View on Nature
Galanin Receptor Subtype 2 Suppresses Cell Proliferation and Induces Apoptosis in p53 Mutant Head and Neck Cancer Cells
TLDR
GALR2 reexpression can inhibit cell proliferation and induce apoptosis in HNSCC cells with mutant p53, and may be a feasible target for H NSCC therapy.
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Prognostic value of type XXII and XXIV collagen mRNA expression in head and neck cancer patients.
TLDR
The results demonstrated that the mRNA levels of COL22A1 and COL24A1 were significantly higher in HNSCC tissues compared to those in the corresponding normal tissues from the same individuals and may play a critical role in the progression of H NSCC.
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Combined therapy with conservative surgery, radiotherapy, and regional chemotherapy for maxillary sinus carcinoma
Current goals for the treatment of carcinoma of the maxillary sinus include the preservation of vision, ability to eat, ability to communicate, and appearance as well as cure.
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Prognostic value of aberrant promoter hypermethylation of tumor-related genes in early-stage head and neck cancer
TLDR
The methylation of some genes was closely related to poor prognosis in early-stage HNSCC, providing strong evidence that these hypermethylated genes are valuable biomarkers for prognostic evaluation.
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Eosinophilic Inflammation in the Middle Ear Induces Deterioration of Bone-Conduction Hearing Level in Patients With Eosinophilic Otitis Media
TLDR
Eosinophilic-inflammation-related substances such as ECP and IgE are closely related to the deterioration of BCHL at high frequencies, and particularly, IgE concentration in MEE is a good indicator of B CHL elevation.
View on Wolters Kluwer
Case of high‐risk epithelioid hemangioendothelioma of the neck
TLDR
A subgroup of EHEs identified as “high‐risk” E HEs because of their size and mitotic activity is associated with an unfavorable clinical course and poor prognosis.
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