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Molecular weight independence of the effect of additive hyaluronic acid on the lubricating characteristics in synovial joints with experimental deterioration.
- K. Mabuchi, T. Obara, K. Ikegami, T. Yamaguchi, T. Kanayama
- Chemistry, Medicine
- Clinical biomechanics
- 1 June 1999
OBJECTIVE To assess the molecular weight dependence of the lubricating characteristics of additive hyaluronic acid in animal joints with experimental deterioration. DESIGN An experimental study in… Expand
Effect of 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), a specific inhibitor of cyclic GMP phosphodiesterase, on human platelet aggregation.
- M. Hagiwara, T. Endo, T. Kanayama, H. Hidaka
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 February 1984
The effects of a novel compound, 1-(3-chloroanilino)-4-phenylphthalazine (MY-5445), on cyclic nucleotide metabolism and in vitro aggregation of human platelets were investigated. The concentrations… Expand
Regulation of hyaluronan synthases in mouse uterine cervix.
- Taro Uchiyama, T. Sakuta, T. Kanayama
- Biology, Medicine
- Biochemical and biophysical research…
- 18 February 2005
We examined the expression pattern of hyaluronan synthase (HAS) mRNAs in the uterine cervix of pregnant mice. The expression levels of HAS-1 and -2 mRNAs peaked at delivery, whereas that of HAS-3… Expand
Analysis of glycosaminoglycans in rabbit cornea after excimer laser keratectomy
- T. Kato, K. Nakayasu, K. Ikegami, T. Obara, T. Kanayama, A. Kanai
- The British journal of ophthalmology
- 1 May 1999
BACKGROUND/AIMS The biochemical basis for the development of subepithelial opacity of the cornea after excimer laser keratectomy has yet to be fully defined. The aim of this study was to evaluate the… Expand
Topical ER36009, a RARγ-selective retinoid, decreases abdominal white adipose tissue and elicits changes in expression of genes related to adiposity and thermogenesis
Chronic topical treatment of rats with a new RARγ-selective retinoid, ER36009, resulted in a significant reduction of epididymal white adipose tissue and a significant increase of interscapular brown… Expand
Marked improvement induced in photoaged skin of hairless mouse by ER36009, a novel RARγ‐specific retinoid, but not by ER35794, an RXR‐selective agonist
Background Photoaging (premature skin aging) results largely from repeated exposure of the skin to ultraviolet (UV) radiation from the sun. Topical all‐trans retinoic acid (RA), the only agent that… Expand
Vasodilation produced by prostacyclin (PGI2) and 9(O)-thiaprostacyclin (PGI2-S) in the canine femoral circulation.
- D. Horii, T. Kanayama, M. Mori, M. Shibasaki, S. Ikegami
- European journal of pharmacology
- 1 October 1978
The action of 9(0)-thiaprostacyclin (PGI2-S) was compared with that of prostacyclin (PGI2) and papaverine in the femoral circulation of dogs. PGI2-S, injected into the dog femoral artery in a dose of… Expand
Biphasic accumulation of leukocytes in rat cardiac infarct tissue caused by leukotriene B4 and complement.
- M. Katori, T. Kanayama, K. Sasaki, A. Ueno, M. Takagi, S. Yamashina
- Japanese journal of pharmacology
An initial increase (3-12 hr) in the polymorphonuclear leukocytes (PMN) counts after ligation of the rat left main coronary artery was reduced by 49.4% (at 12 hr) by a 5-lipoxygenase inhibitor,… Expand
A new prostacyclin analog, KP-10614, inhibits platelet-polymorphonuclear leukocyte interaction and limits experimental infarct size in rat heart.
A chemically stable prostacyclin analog, KP-10614 [(4Z,16S)-4, 5, 18, 18, 19, 19-hexadehydro-16,20-dimethyl-delta 6(9 alpha)-9(O)-methano-prostaglandin I1], was synthesized to increase the… Expand
Comedolytic effect of a novel RARgamma-specific retinoid, ER36009: comparison with retinoic acid in the rhino mouse model.
In addition to natural retinoids, new synthetic retinoids, such as adapalene and tazarotene, are currently available for the treatment of acne. In this study, we evaluated the comedolytic effect of a… Expand