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Comparison of Antipsychotic Activity and Discriminative Stimulus Effects of the Novel Acylprolyltyrosine Containing Compound, GZR-123, and Sulpiride
In contrast to GZR-123, which did not provoke a sedative effect, sulpiride in higher discriminable doses caused sedation, which stems probably from the motivational, but not from the motor deficit. Expand
Anticompulsive Activity of a New Pyrazolo[C]Pyridine Derivative GIZh-72 under Conditions of Unpredictable Chronic Mild Stress
The results indicate that GIZh-72 holds much promise for pharmacotherapy of obsessive-compulsive disorder. Expand
Expression of hormonal carcinogenesis genes and related regulatory microRNAs in uterus and ovaries of DDT-treated female rats
Assessment of changes in expression of key genes involved in hormonal carcinogenesis as well as potentially related regulatory oncogenic/tumor suppressor microRNAs and their target genes in the uterus and ovaries of female Wistar rats during single and chronic multiple-dose DDT exposure suggests epigenetic effects induced by DDT as a potential carcinogen may be based on at least two mechanisms. Expand
Pharmacological Aspects of Neuro-Immune Interactions.
The purpose of this review is to analyze the experimental and clinical data related to central effects of drugs with antiviral or/and immunotropic activity, and to discover the relationship of these effects with changes in reactivity of immune system and proinflammatory response. Expand
[Unpredictable chronic mild stress effects on antidepressants activities in forced swim test].
The injection rates and duration of unpredictable mild chronic stress are the parameters that determine the efficiency of antidepressants in the mouse forced swimming test. Expand
Effects of Physicochemical Forms of Phenazepam and Panavir on Their Action at Ultra-Low Doses
Phenazepam was shown to possess activity in ultra-low doses only in disperse state, in the form of nanoparticles with a diameter <100-300 nm; these nanoparticles appear as micelles of surface active substances and solvated. Expand
Effects of Unpredictable Chronic Mild Stress on the Effects of Antidepressants in the Forced Swimming Test
The effects of unpredictable chronic mild stress on the effects of the tricyclic antidepressant amitriptyline (10 mg/kg) and the selective serotonin reuptake inhibitor fluoxetine (20 mg/kg) in theExpand
Physicochemical properties of high-molecular-weight plant polysaccharide of hexose glycoside class (Panavir) with antiviral activity
A high-molecular-weight plant polysaccharide belonging to the hexose glycoside (HG) class and composed of rhamnose (2–10%), arabinose (3–15%), glucose (10–67%), galactose (2–27%), xylose (0.1–3%),Expand
Anxiety and Predisposition to Audiogenic Epilepsy in Rats of Different Genotypes
The anxiety parameters in Krushinskii−Molodkina rats were evaluated after injection of anticonvulsant levetiracetam and anxiolytic afobazol. Expand