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[Clinical application of stellate ganglion morphine infiltration for chronic pain relief].
Anti-obesity and anti-diabetic activities of a new beta3 adrenergic receptor agonist, (S)-(Z)-[4-[[1-[2-[(2-hydroxy-3-phenoxypropyl)]amino]ethyl]-1-propenyl] phenoxy] acetic acid ethanedioic acid
The results indicated that SWR-0342SA is a selective beta3-AR agonist, and possesses potent anti-di diabetic activity, and that the anti-obesity activity is inferior to theAnti-diabetic activity. Expand
Antiulcer agents. III. Synthesis and antiulcer activity of N-[3-(3-piperidinomethylphenoxy)propyl]pentacyclo[,5).0(3,8).0 (4,7)]-octane carboxamides and related compounds.
Compounds 26a and 26q exhibited H2-receptor antagonist potency (in vitro) comparable to that of ranitidine, but did not inhibit histamine-stimulated acid secretion (in vivo) in the gastric fistula rat model, when orally administered in the dose range at which antiulcer and cytoprotective activities were seen. Expand
Binding and functional affinity of some newly synthesized phenethylamine and phenoxypropanolamine derivatives for their agonistic activity at recombinant human β3‐adrenoceptor
Thirteen new compounds have been evaluated for their potencies and efficacies asβ3‐adrenoceptor agonists on human β3‐ adrenoceptor expressed in COS‐7 and Chinese hamster ovary (CHO) cells using radio ligand binding assay and cyclic AMP (cAMP) accumulation assay. Expand
Pharmacological profiles of a new antiulcer agent, SWR-215.
Results suggest that SWR-215 possesses both durable antisecretory and mucosal protective effects, and is expected to be a useful drug for the treatment of patients with peptic ulcers. Expand
Molecular characterization of pharmacological properties and selectivity of SWR-0315NA for beta3-adrenoceptors.
Results indicate that although SWR-0315NA has lower binding selectivity towards beta-AR subtypes, it is a selective agonist with high intrinsic activity for beta(3)-AR as compared with (-)-isoproterenol. Expand
Comparison of the binding affinity of some newly synthesized phenylethanolamine and phenoxypropanolamine compounds at recombinant human β‐ and α1‐adrenoceptor subtypes
Six new compounds were evaluated and the binding affinities for human α1‐adrenoceptors expressed in Chinese hamster ovary (CHO) cells were compared using a radioligand‐binding assay to confirm the finding of this manuscript that this phenoxypropanolamine group of β2‐phenyl‐2‐hydroxyethyl ligands could also be used as α1-adrenOceptor ligands. Expand
On the existence of time-periodic solutions of some non-linear evolution equation †
In this paper we study time-periodic solutions for Dirichlet type boundary value problems for some non-linear evolution equations with time-periodic forcing term. Our equations include semi-linearExpand
Time Decay and Scattering for Some Nonlinear Wave Equation
Recently J. M. Chadam proved a global existence and uniqueness theorem to the Cauchy problem for nonlinear Klein-Gordon equations (in three dimensional space) with nonlinear term G (x, t, u9 uX9 ut)Expand