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Biochemical changes in unilateral brain injury in the rat: A possible role of free fatty acid accumulation
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Interleukin-1 induces analgesia in mice by a central action.
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Central and peripheral analgesic action of non-acidic non-steroidal anti-inflammatory drugs in mice and rats.
TLDR
The results suggest that non-acidic NSAIDs produce their anti-writhing action through both central and peripheral mechanisms, and that aminopyrine showed more of anti-inflammatory potency when administered i.p.v. than i.c.s.
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Effect of a prostaglandin E1 derivative (OP-1206) and acetylsalicylic acid on electrically induced thrombosis in guinea-pig mesenteric artery and its modification by an inhibitor of prostaglandin I2…
TLDR
The antithrombotic effect of a prostaglandin E1 derivative, OP-1206 X alpha-CD, was compared with that of acetylsalicylic acid (ASA) in a electrically induced thrombosis model of guinea-pig mesenteric arteries using intact animals and animals subjected to the superfusion of tranylcypromine over their mesentery.
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Anti-inflammatory action of interleukin 1 through the pituitary-adrenal axis in rats.
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Effects of intraseptally injected dopamine and noradrenaline on hippocampal synchronized theta wave activity in rats.
TLDR
The results suggest that DA and NA, when injected into the medial septum (MSN) and MSN, heighten the functional level of the hippocampus.
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Antihypertensive mechanism of alacepril: effect on norepinephrine-induced vasoconstrictive response in vitro and in vivo.
TLDR
Alacepril showed a dose-related antihypertensive effect which was slower in onset and longer lasting than that of equimolar dose of captopril, which might contribute partly to the reduced sensitivity of the sympathetic nervous system in peripheral vasculature.
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The pharmacological profile of 2-(8-methyl-10,11-dihydro-11-oxodibenz[b,f]oxepin-2-yl)propionic acid (AD-1590), a new non-steroidal anti-inflammatory agent with potent antipyretic activity.
TLDR
AD-1590 showed the potent inhibitory activity on acute and subacute inflammation such as carrageenin hind paw edema, acetic acid-induced increased vascular permeability, UV-erythema and felt pellet-induced granuloma formation, and its potency was on the whole comparable to that of indomethacin.
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Protective effect of prostaglandins D2, E1 and I2 against cerebral hypoxia/anoxia in mice
TLDR
General depression of CNS function appears not to be responsible for the PGD2, PGE1- and PGI2-induced increase in cerebral resistance to hypoxia, and it was suggested that these protective effect was related to an increase in the energy reserve available or a decrease in the cerebral energy demand.
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General pharmacology of the novel antiepileptic compound zonisamide. 1st communication: effects on central nervous system.
The effects of 1,2-benzisoxazole-3-methanesulfonamide (zonisamide, AD-810, CI-912), an antiepileptic compound, on the central nervous system were compared with those of carbamazepine and…
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