T. Kôno

Publications191
h-index29
Citations3,535
Highly Influential Citations31
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Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site.
  • K. Suzuki, T. Kôno
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 May 1980
The glucose transport activity of fat cells was assayed in a cell-free system. The activity was solubilized and incorporated into egg-lecithin liposomes. The carrier-mediated glucose transport… Expand
  • 847
  • 10
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Biological activities of angiotensin II-(1-6)-hexapeptide and angiotensin II-(1-7)-heptapeptide in man.
Biological activities of angiotensin II-(1-6)-hexapeptide [ANG-(1-6)] and angiotensin II-(1-7)-heptapeptide [ANG-(1-7)] were studied in 5 normal men and 3 patients with Bartter's syndrome. The… Expand
  • 54
  • 5
Isolation of skeletal muscle cell membrane and some of its properties.
A procedure is described for the isolation of empty tubular cell membrane-like structures from rat skeletal muscle. The procedure resulted in a purification of about 140-fold in terms of protein… Expand
  • 116
  • 2
Kinetics of fermentation processes
  • T. Kôno, T. Asai
  • Chemistry, Medicine
  • Biotechnology and bioengineering
  • 1 May 1969
Kinetic studies on fermentation processes were made and a general equation of production rate was newly presented applying the kinetic theory on mierobial cell growth which was reported previously by… Expand
  • 62
  • 2
Evidence that translocation of the glucose transport activity is the major mechanism of insulin action on glucose transport in fat cells.
The glucose transport activity associated with the plasma membrane-rich and Golgi-rich fractions of fat cells was determined after they were reconstituted into egg lecithin liposomes. When the two… Expand
  • 170
  • 1
Insulin-sensitive phosphodiesterase. Its localization, hormonal stimulation, and oxidative stabilization.
As it was shown previoulsy by others, the membrane-bound phosphodiesterase (cyclic adenosine 3':5'-monophosphate phosphodiesterase) of rat epididymal fat cells was stimulated when intact cells were… Expand
  • 144
  • 1
Biological activity of des-asp1-angiotensin II (angiotensin III) in man.
Effects of des-asp1-angiotensin II (angiotensin III) on blood pressure and aldosterone secretion were examined in man. Angiotensin III was equipotent with val5-angiotensin II amide in the stimulation… Expand
  • 44
  • 1
An improved method of reconstitution of adipocyte glucose transport activity.
Abstract The glucose transport activity of rat epididymal fat cells was reconstituted into egg lecithin liposomes with a high degree of reproducibility. The activity was solubilized with 20 m m… Expand
  • 35
  • 1
Biological activity of des-Asp1-angiotensin I in man.
The biological activity of des-Asp1-angiotensin I (des-Asp1-AI) was studied in five normal men. An iv infusion of 300 ng (258 pmol)/kg.min des-Asp1-AI caused a remarkable rise in blood pressure, a… Expand
  • 22
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Modification of E. coli L-asparaginase with polyethylene glycol: disappearance of binding ability to anti-asparaginase serum.
Abstract L-Asparaginase from Escherichia coli A-1-3 was modified with activated polyethylene glycols (2-0-methoxypolyethylene glycol-4,6-dichloro-s-triazine) with molecular weights of 750, 1900 and… Expand
  • 95
  • 1