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Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials
TLDR
Endovascular thrombectomy is of benefit to most patients with acute ischaemic stroke caused by occlusion of the proximal anterior circulation, irrespective of patient characteristics or geographical location, and will have global implications on structuring systems of care to provide timely treatment. Expand
Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke.
TLDR
In patients receiving intravenous t-PA for acute ischemic stroke, thrombectomy with the use of a stent retriever within 6 hours after onset improved functional outcomes at 90 days. Expand
Randomized assessment of rapid endovascular treatment of ischemic stroke.
BACKGROUND Among patients with a proximal vessel occlusion in the anterior circulation, 60 to 80% of patients die within 90 days after stroke onset or do not regain functional independence despiteExpand
Thrombectomy within 8 hours after symptom onset in ischemic stroke.
TLDR
Among patients with anterior circulation stroke who could be treated within 8 hours after symptom onset, stent retriever thrombectomy reduced the severity of post-stroke disability and increased the rate of functional independence. Expand
Endovascular therapy after intravenous t-PA versus t-PA alone for stroke.
TLDR
The trial showed similar safety outcomes and no significant difference in functional independence with endovascular therapy after intravenous t-PA, as compared with intravenoust-PA alone. Expand
Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis.
TLDR
Warfarin was associated with significantly higher rates of adverse events and provided no benefit over aspirin in this trial, and aspirin should be used in preference to warfarin for patients with intracranial arterial stenosis. Expand
Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial
TLDR
The Solitaire Flow Restoration Device achieved substantially better angiographic, safety, and clinical outcomes than did the Merci Retrieval System and might be a future treatment of choice for endovascular recanalisation in acute ischaemic stroke. Expand
Time to Treatment With Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis.
TLDR
The period in which endovascular thrombectomy is associated with benefit, and the extent to which treatment delay is related to functional outcomes, mortality, and symptomatic intracranial hemorrhage are characterized are characterized. Expand
Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial
TLDR
Patients who have had large vessel occlusion strokes but are ineligible for (or refractory to) intravenous tissue plasminogen activator should be treated with the Trevo Retriever in preference to the Merci retriever. Expand
MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study
TLDR
Target mismatch patients who had early reperfusion after endovascular stroke treatment had more favourable clinical outcomes and a randomised controlled trial of endov vascular treatment for patients with the target mismatch profile is warranted. Expand
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