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Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
Pituitary adenylate cyclase-activating polypeptide (PACAP) is known to broadly regulate the cellular stress response. In contrast, it is unclear if the PACAP–PAC1 receptor pathway has a role in humanExpand
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How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD.
Exposure to traumatic events that produce extreme fear and horror is all too common in both military and civilian populations, but not all individuals develop posttraumatic stress disorder (PTSD) asExpand
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Impaired fear inhibition is a biomarker of PTSD but not depression
Background: A central problem in posttraumatic stress disorder (PTSD) is a reduced capacity to suppress fear under safe conditions. Previously, we have shown that combat‐related PTSD patients haveExpand
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Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
This corrects the article DOI: 10.1038/nature09856
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Association between childhood maltreatment and adult emotional dysregulation in a low-income, urban, African American sample: moderation by oxytocin receptor gene.
The ability to effectively regulate emotions and a secure attachment style are critical for maintaining mental health across the life span. The experience of childhood maltreatment interferes withExpand
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A randomized, double-blind evaluation of D-cycloserine or alprazolam combined with virtual reality exposure therapy for posttraumatic stress disorder in Iraq and Afghanistan War veterans.
OBJECTIVE The authors examined the effectiveness of virtual reality exposure augmented with D-cycloserine or alprazolam, compared with placebo, in reducing posttraumatic stress disorder (PTSD) due toExpand
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Fear Extinction in Traumatized Civilians with Posttraumatic Stress Disorder: Relation to Symptom Severity
BACKGROUND The symptoms of posttraumatic stress disorder (PTSD) can be explained, at least in part, as an inability to inhibit learned fear during conditions of safety. Our group has shown that fearExpand
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Posttraumatic stress disorder may be associated with impaired fear inhibition: Relation to symptom severity
One of the central problems in posttraumatic stress disorder (PTSD) is the inability to suppress fear even under safe conditions. The neural underpinnings of fear are clinically relevant but poorlyExpand
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Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder.
Many features of posttraumatic stress disorder (PTSD) can be linked to exaggerated and dysregulated emotional responses. Central to the neurocircuitry regulating emotion are functional interactionsExpand
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Estrogen Levels Are Associated with Extinction Deficits in Women with Posttraumatic Stress Disorder
BACKGROUND Women are twice as likely to develop posttraumatic stress disorder (PTSD) than men. As shown in our previous work, the inability to suppress fear responses in safe conditions may be aExpand
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