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Quantitative Measurement of Regional Cerebral Blood Flow and Oxygen Metabolism in Man Using 15O and Positron Emission Tomography: Theory, Procedure, and Normal Values
A method is described for quantifying regional cerebral blood flow (rCBF), oxygen extraction (rOER), and oxygen utilization (rCMRO2) in man noninvasivey, using inhaled 15O-labeled CO2 and O2 andExpand
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Physical characteristics of the ECAT EXACT3D positron tomograph.
The 'EXACT3D' positron tomograph, which is now in routine clinical research use, was developed with the aim of achieving unprecedented sensitivity, high spatial and temporal resolution and simplicityExpand
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Spectral Analysis of Dynamic PET Studies
  • V. Cunningham, T. Jones
  • Computer Science, Medicine
  • Journal of cerebral blood flow and metabolism…
  • 1 January 1993
We describe a new technique for the analysis of dynamic positron emission tomography (PET) studies in humans, where data consist of the time courses of label in tissue regions of interest and in arterial blood, following the administration of radiolabeled tracers. Expand
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Physical performance of a positron tomograph for brain imaging with retractable septa.
Performance characteristics of a new design of positron tomograph with automatically retractable septa for brain imaging have been studied. The device, consisting of block BGO detectors (8 x 8Expand
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Patterns of cerebral blood flow in schizophrenia.
Positron emission tomography was used to study the relationship between rCBF and symptom profiles in 30 schizophrenic patients. Factor analysis confirmed that the symptoms segregated into threeExpand
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Myocardial tissue fraction--correction for partial volume effects and measure of tissue viability.
We have compared two independent methods of correcting the systematic underestimation in measurements of myocardial radiotracer concentration due to wall motion and small transmural wall thickness inExpand
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Correction for the Presence of Intravascular Oxygen-15 in the Steady-State Technique for Measuring Regional Oxygen Extraction Ratio in the Brain: 1. Description of the Method
  • A. Lammertsma, T. Jones
  • Materials Science, Medicine
  • Journal of cerebral blood flow and metabolism…
  • 1 December 1983
The oxygen-15 steady-state inhalation technique provides quantitative values of regional cerebral blood flow, fractional oxygen extraction, and oxygen utilisation. These last two, however, have beenExpand
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Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphate.
PURPOSE Clinical evaluation of novel agents that target tumor blood vessels requires pharmacodynamic end points that measure vascular damage. Positron emission tomography (PET) was used to measureExpand
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Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals
Abstract. With the stated aim of scanning small regions of interest in mice, several high-resolution positron emission tomographic (PET) systems are presently under development. Some, however, haveExpand
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Benzodiazepine Receptor Quantification in vivo in Humans Using [11C]Flumazenil and PET: Application of the Steady-State Principle
Carbon-11-labeled flumazenil combined with positron emission tomography (PET) was used to measure the concentration (Bmax) of the benzodiazepine (Bz) receptor in the brain and its equilibriumExpand
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