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Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude
No Genetic Vertigo Peoples living in high altitudes have adapted to their situation (see the Perspective by Storz). To identify gene regions that might have contributed to high-altitude adaptation inExpand
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International network of cancer genome projects
The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical andExpand
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Complete Resequencing of 40 Genomes Reveals Domestication Events and Genes in Silkworm (Bombyx)
The Taming of the Silkworm Silkworms, Bombyx mori, represent one of the few domesticated insects, having been domesticated over 10,000 years ago. Xia et al. (p. 433, published online 27 August)Expand
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Extensive X-linked adaptive evolution in central chimpanzees
Surveying genome-wide coding variation within and among species gives unprecedented power to study the genetics of adaptation, in particular the proportion of amino acid substitutions fixed byExpand
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Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex
Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor:Expand
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Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor
The synthesis, preclinical profile, and in vivo efficacy in rat xenograft models of the novel and selective anaplastic lymphoma kinase inhibitor 15b (LDK378) are described. In this initial report,Expand
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Structure and Functional Implications of the Human Rad9-Hus1-Rad1 Cell Cycle Checkpoint Complex*
Cellular DNA lesions are efficiently countered by DNA repair in conjunction with delays in cell cycle progression. Previous studies have demonstrated that Rad9, Hus1, and Rad1 can form aExpand
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Probabilistic Framework for Liquefaction Potential by Shear Wave Velocity
This paper presents a new empirical equation for assessing liquefaction resistance of soils based on shear wave velocity Vs and the results of probabilistic analyses based on this empirical equation.Expand
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Chitosan-poly(lactide-co-glycolide) microsphere-based scaffolds for bone tissue engineering: in vitro degradation and in vivo bone regeneration studies.
Natural polymer chitosan and synthetic polymer poly(lactide-co-glycolide) (PLAGA) have been investigated for a variety of tissue engineering applications. We have previously reported the fabricationExpand
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Evaluation of the esthetic effect of resin cements and try-in pastes on ceromer veneers.
OBJECTIVE To evaluate the influence of various shades of resin cements on the final color of ceromer veneers and analyse the agreement of resin cements and corresponding try-in pastes. METHODSExpand
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