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IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs
It is suggested that the vascular function of IL-20 involves endothelial cell organization, vessel maturation, and remodeling, and delivery ofIL-20 to the ischemic muscle tissue significantly improves arteriogenesis and blood perfusion in a rat hind-limb model. Expand
VEGF blockade decelerates the growth of a murine experimental osteosarcoma.
Overall, data suggest that retrovirus-mediated sFLT-1 gene modification decelerates the osteosarcoma tumor growth in this murine model. Expand
Differential roles of PDGFR‐α and PDGFR‐β in angiogenesis and vessel stability
It is demonstrated that PDGFR‐β receptor is essen‐tial for vascular stability, and a combination of PDGF‐AB and FGF‐2 would be optimal proangiogenic agents for the treatment of ischemic diseases. Expand
Current research in the pathogenesis of aseptic implant loosening associated with particulate wear debris.
This review summarizes current concepts of how wear debris causes osteolysis, and describes the interaction and effects of wear debris on functions of primary cell types involved in osteolytic disease. Expand
Molecular mechanism underlying the tumor-promoting functions of carcinoma-associated fibroblasts
This review describes the available directions of CAF-based target therapy and suggest research areas which need to be further explored so as to deepen the understanding of tumor evolution and provide new therapeutic targets for cancer treatment. Expand
Titanium particle-challenged osteoblasts promote osteoclastogenesis and osteolysis in a murine model of periprosthestic osteolysis.
T titanium alloy particles were shown to interfere with the growth, maturation, and functions of the bone marrow osteoblast progenitor cells and appear to express mediators that regulate osteoclastogenesis and peri-prosthetic osteolysis. Expand
Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice
Investigating whether progranulin (PGRN), a chondroprotective growth factor, is associated with IVD degeneration found it to play a critical role in homeostasis of IVD, and may serve as a potential molecular target for prevention and treatment of disc degenerative diseases. Expand
Efficacy of hyperbaric oxygen on survival of random pattern skin flap in diabetic rats.
  • T. Zhang, W. Gong, +5 authors T. Jia
  • Medicine
  • Undersea & hyperbaric medicine : journal of the…
  • 1 September 2007
Beneficial effects of HBO2 in improving diabetic rat dorsal skin flap survival were demonstrated and new-growth capillary vessel and granulation tissue thickness were statistically different between the two groups. Expand
Combination Gene Therapy Targeting On Interleukin-1β and Rankl for Wear Debris Induced Aseptic Loosening
Real-time PCR data indicated that the action of IL-1Ra gene therapy may be mediated via the JNK1 pathway, while the reduction of osteoclastogenesis by OPG gene modification may be regulated by c-Fos expression. Expand
Expression of hepatocyte growth factor and c-Met in non-small-cell lung cancer and association with lymphangiogenesis.
The expression of HGF‑α or c‑Met was closely correlated with VEGF‑C, LMVD and metastases of lymph nodes, indicating that HGF‐α, c‐Met and VEGf‑C may perform important and collaborative actions in lymphangiogenesis and lymphatic metastasis of primary NSCLC. Expand