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Principles of Neural Science
Contents. Preface. Acknowledgments. Contributors. Part I: The Neurology of Behavior. Part II: Cell and Molecular Biology of the Neuron. Part III: Elementary Interactions Between Neurons: SynapticExpand
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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
BackgroundSeveral Cre reporter strains of mice have been described, in which a lacZ gene is turned on in cells expressing Cre recombinase, as well as their daughter cells, following Cre-mediatedExpand
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A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube
Distinct classes of neurons are generated at defined positions in the ventral neural tube in response to a gradient of Sonic Hedgehog (Shh) activity. A set of homeodomain transcription factorsExpand
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Neuronal specification in the spinal cord: inductive signals and transcriptional codes
  • T. Jessell
  • Biology, Medicine
  • Nature Reviews Genetics
  • 1 October 2000
Neural circuits are assembled with remarkable precision during embryonic development, and the selectivity inherent in their formation helps to define the behavioural repertoire of the matureExpand
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Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling
Distinct classes of motor neurons and ventral interneurons are generated by the graded signaling activity of Sonic hedgehog (Shh). Shh controls neuronal fate by establishing different progenitor cellExpand
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Directed Differentiation of Embryonic Stem Cells into Motor Neurons
Inductive signals and transcription factors involved in motor neuron generation have been identified, raising the question of whether these developmental insights can be used to direct stem cells toExpand
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Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity
Antibodies that block Sonic Hedgehog (SHH) signaling have been used to show that SHH activity is required for the induction of floor plate differentiation by the notochord and independently for theExpand
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Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
The cellular interactions that control the differentiation of dorsal cell types from neural progenitors have been examined in neural plate explants. Certain genes that are expressed in the dorsalExpand
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Coordinate Regulation of Motor Neuron Subtype Identity and Pan-Neuronal Properties by the bHLH Repressor Olig2
Within the developing vertebrate nervous system, the mechanisms that coordinate neuronal subtype identity with generic features of neuronal differentiation are poorly defined. We show here that aExpand
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Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
During vertebrate development, the specification of distinct cell types is thought to be controlled by inductive signals acting at different concentration thresholds. The degree of receptorExpand
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