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Principles of Neural Science
Contents. Preface. Acknowledgments. Contributors. Part I: The Neurology of Behavior. Part II: Cell and Molecular Biology of the Neuron. Part III: Elementary Interactions Between Neurons: SynapticExpand
Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus
In contrast to existing lacZ reporter lines, where lacZ expression cannot easily be detected in living tissue, the EYFP and ECFP reporter strains are useful for monitoring the expression of Cre and tracing the lineage of these cells and their descendants in cultured embryos or organs. Expand
A Homeodomain Protein Code Specifies Progenitor Cell Identity and Neuronal Fate in the Ventral Neural Tube
Cross-repressive interactions between class I and class II proteins appear to refine and maintain these progenitor domains, which generate a distinct class of postmitotic neurons in the ventral third of the neural tube. Expand
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
  • T. Jessell
  • Biology, Medicine
  • Nature Reviews Genetics
  • 1 October 2000
The mechanisms that specify the identity of neural cells have been examined in many regions of the nervous system and reveal a high degree of conservation in the specification of cell fate by key signalling molecules. Expand
Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling
P Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain. Expand
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
The results suggest that LIM homeobox genes contribute to the generation of motor neuron diversity and may confer subclasses of motor neurons with the ability to select specific axon pathways, thereby initiating the topographic organization of motor projections. Expand
Directed Differentiation of Embryonic Stem Cells into Motor Neurons
It is shown that developmentally relevant signaling factors can induce mouse embryonic stem cells to differentiate into spinal progenitor cells, and subsequently into motor neurons, through a pathway recapitulating that used in vivo. Expand
Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity
The ambient SHH concentration during the late period determines whether ventralized progenitors differentiate into motor neurons or interneurons, thus defining the pattern of neuronal cell types generated in the neural tube. Expand
Coordinate Regulation of Motor Neuron Subtype Identity and Pan-Neuronal Properties by the bHLH Repressor Olig2
Olig2 has a critical role in integrating diverse features of motor neuron differentiation in the developing spinal cord and depends on regulatory interactions with progenitor homeodomain proteins. Expand
Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
The cellular interactions that control the differentiation of dorsal cell types from neural progenitors have been examined in neural plate explants and appear to be initiated at the neural plate stage and to involve the opponent activities of a BMP-mediated dorsalizing signal from the epidermal ectoderm and a SHH-mediated ventralizing signalFrom the notochord. Expand